2015
The Histone Methyltransferase Setd8 Is Essential for Mammalian Erythropoiesis
Malik J, Getman M, Lillis J, Gallagher P, Steiner L. The Histone Methyltransferase Setd8 Is Essential for Mammalian Erythropoiesis. Blood 2015, 126: 3577. DOI: 10.1182/blood.v126.23.3577.3577.Peer-Reviewed Original ResearchCell cycle progressionNuclear condensationTranscriptional regulationMammalian erythropoiesisErythroid maturationGATA2 expressionErythroid cellsCycle progressionHistone H4 lysine 20Sole histone methyltransferaseGFP fusion proteinH4 lysine 20Histone methyltransferase Setd8Erythroid transcription factorsErythroid-specific genesEarly embryonic lethalityGlobal transcriptome analysisDNA damage responseMajority of transcriptsRNA-seq analysisCell cycle checkpointsKey regulatory regionsCommitted erythroid progenitorsErythro-myeloid progenitorsPrimary human erythroblasts
2014
Global transcriptome analyses of human and murine terminal erythroid differentiation
An X, Schulz VP, Li J, Wu K, Liu J, Xue F, Hu J, Mohandas N, Gallagher PG. Global transcriptome analyses of human and murine terminal erythroid differentiation. Blood 2014, 123: 3466-3477. PMID: 24637361, PMCID: PMC4041167, DOI: 10.1182/blood-2014-01-548305.Peer-Reviewed Original ResearchConceptsTerminal erythroid differentiationErythroid differentiationGene expressionMurine terminal erythroid differentiationStage-specific transcriptomesDifferentiation stageGlobal transcriptome analysisStage-specific patternsRNA sequencing analysisGene expression profilesDistinct developmental stagesMurine transcriptomesFluorescence-activated cell sortingTranscriptional spaceErythroid developmentMurine erythroblastsTranscriptome analysisUnique transcriptomeBioinformatics analysisPerturbed erythropoiesisTranscriptomeExpression profilesErythroid disordersDevelopmental stagesSequencing analysis