2001
Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases
Oppenheim R, Flavell R, Vinsant S, Prevette D, Kuan C, Rakic P. Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases. Journal Of Neuroscience 2001, 21: 4752-4760. PMID: 11425902, PMCID: PMC6762357, DOI: 10.1523/jneurosci.21-13-04752.2001.Peer-Reviewed Original ResearchConceptsCell deathGenetic deletionExtensive cytoplasmic vacuolizationPro-apoptotic proteasesCaspase familySpecific caspasesChromatin condensationNonapoptotic pathwaysPostmitotic neuronsCaspase-9Mammalian neuronsCell typesDeath processSpecific perturbationsCaspase-3Altered morphologyCaspasesNuclear changesKey membersDeletionUTP nickCytoplasmic vacuolizationElectron microscopic levelTerminal deoxynucleotidyl transferase-mediated biotinylated UTP nickNeuronal populations
1998
Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex
Komuro H, Rakic P. Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex. Journal Of Neuroscience 1998, 18: 1478-1490. PMID: 9454856, PMCID: PMC6792738, DOI: 10.1523/jneurosci.18-04-01478.1998.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornCell MovementCerebellar CortexGranulocytesMiceMice, Inbred StrainsNeuronsPurkinje CellsTime FactorsConceptsGranule cellsInternal granular layerBergmann glial fibersGlial fibersMost granule cellsMossy fiber terminalsLocal environmental cuesPurkinje cell layerGranular layerAcute cerebellar slice preparationCerebellar slice preparationSynaptic contactsGranule cell movementSlice preparationFiber terminalsBergmann gliaCerebellar cortexPostmitotic neuronsNeuronal migrationNeuronsSomaCell layerCerebellar neurogenesisPresent studyDifferent cellular microenvironments
1996
Intracellular Ca2+ Fluctuations Modulate the Rate of Neuronal Migration
Komuro H, Rakic P. Intracellular Ca2+ Fluctuations Modulate the Rate of Neuronal Migration. Neuron 1996, 17: 275-285. PMID: 8780651, DOI: 10.1016/s0896-6273(00)80159-2.Peer-Reviewed Original Research
1995
Dynamics of granule cell migration: a confocal microscopic study in acute cerebellar slice preparations
Komuro H, Rakic P. Dynamics of granule cell migration: a confocal microscopic study in acute cerebellar slice preparations. Journal Of Neuroscience 1995, 15: 1110-1120. PMID: 7869087, PMCID: PMC6577849, DOI: 10.1523/jneurosci.15-02-01110.1995.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornCell MembraneCell MovementCerebellumMiceMice, Inbred StrainsMicroscopy, ConfocalNeuronsTime FactorsConceptsCell movementCell migrationPlasma membraneShort stationary phaseCerebellar slice preparationGranule cell migrationMolecular mechanismsMembrane flowConfocal microscopic studiesIndividual cellsNeuronal migrationConfocal microscopyCytological aspectsDil crystalsCellsMembraneBergmann glial fibersGranule cellsMigrationMicrons/hrOld micePostnatal lifeConsiderable variationAcute cerebellar slice preparationStationary phase
1978
Mechanisms of Cortical Development: A View From Mutations in Mice
Caviness V, Rakic P. Mechanisms of Cortical Development: A View From Mutations in Mice. Annual Review Of Neuroscience 1978, 1: 297-326. PMID: 386903, DOI: 10.1146/annurev.ne.01.030178.001501.Peer-Reviewed Original Research
1975
The correlation of the time of origin of neurons with their axonal projection: the combined use of [3H]thymidine autoradiography and horseradish peroxidase histochemistry
Nowakowski R, La Vail J, Rakic P. The correlation of the time of origin of neurons with their axonal projection: the combined use of [3H]thymidine autoradiography and horseradish peroxidase histochemistry. Brain Research 1975, 99: 343-348. PMID: 1182549, DOI: 10.1016/0006-8993(75)90034-7.Peer-Reviewed Original Research