2001
Telencephalic origin of human thalamic GABAergic neurons
Letinic K, Rakic P. Telencephalic origin of human thalamic GABAergic neurons. Nature Neuroscience 2001, 4: 931-936. PMID: 11528425, DOI: 10.1038/nn0901-931.Peer-Reviewed Original ResearchConceptsNon-primate mammalian speciesHomeodomain-containing proteinMigratory pathwaysThalamic association nucleiVital dye labelingEvolutionary expansionMammalian speciesAssociation nucleiTelencephalic cellsRodent embryosGuidance cuesChemorepulsive cuesMigration assaysOrganotypic slice culturesDye labelingProliferative zoneNon-human primatesGABAergic neuronsDiencephalic neuronsPathwayDorsal thalamusTelencephalic originGanglionic eminenceSlice culturesNeurons
2000
Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
Haydar T, Wang F, Schwartz M, Rakic P. Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones. Journal Of Neuroscience 2000, 20: 5764-5774. PMID: 10908617, PMCID: PMC3823557, DOI: 10.1523/jneurosci.20-15-05764.2000.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsAntimetabolitesBromodeoxyuridineCell DifferentiationCell DivisionCell MovementCerebral VentriclesClone CellsExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFetusGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGlutamic AcidKainic AcidMiceMice, Inbred ICRMuscimolNeocortexNeuronsOrgan Culture TechniquesStem CellsConceptsVentricular zoneNeural progenitor populationsNeural progenitor proliferationSubventricular zoneProgenitor populationsCell cycleProgenitor cloneProgenitor proliferationEmbryonic cerebrumNeocortical growthProliferationDifferential responsivenessRecent studiesBromodeoxyuridine uptakeDifferential modulationOrganotypic slice culturesClassical neurotransmitters GABAOpposite effectNeurotransmitter GABARelative contributionClonesDisparate effectsRegulationSlice culturesSpecific GABA
1999
Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1
Haydar T, Bambrick L, Krueger B, Rakic P. Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1. Brain Research 1999, 4: 425-437. PMID: 10592354, DOI: 10.1016/s1385-299x(99)00033-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBromodeoxyuridineCell DivisionCell MovementCell SurvivalFemaleFetusFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinIn Situ Nick-End LabelingMiceMice, Inbred ICRMicroscopy, ConfocalMicrotubule-Associated ProteinsNeocortexNeurogliaNeuronsOrgan Culture TechniquesPregnancyConceptsCell deathProper cortical developmentCell-cell interactionsDynamic cellular interactionsQuantitative confocal microscopyDiffusible regulatorsPrimary cell culturesAnalysis of proliferationCellular interactionsCellular mechanismsCortical neurogenesisNeuronal migrationConfocal microscopyCell proliferationNeocortical neurogenesisExperimental manipulationThree-dimensional environmentVivo processesCell culturesNeurogenesisPhysiological methodsTropic supportOrganotypic slice culturesProliferationCortical development
1994
An array of early differentiating cones precedes the emergence of the photoreceptor mosaic in the fetal monkey retina.
Wikler K, Rakic P. An array of early differentiating cones precedes the emergence of the photoreceptor mosaic in the fetal monkey retina. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 6534-6538. PMID: 7912829, PMCID: PMC44237, DOI: 10.1073/pnas.91.14.6534.Peer-Reviewed Original ResearchConceptsFetal monkey retinaMonkey retinaRetinal ganglion cellsSubset of conesRed/green opsinImportant developmental markersGanglion cellsPrimate retinaGreen-sensitive conesDistinct antigensPhotoreceptor phenotypeRetinaMonoclonal antibodiesPhotoreceptor mosaicCone differentiationDevelopmental markersAntibodiesImmature regionsSame patternGreen opsinsAntigenSynaptogenesisSubset
1993
Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage
Bourgeois J, Rakic P. Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage. Journal Of Neuroscience 1993, 13: 2801-2820. PMID: 8331373, PMCID: PMC6576672, DOI: 10.1523/jneurosci.13-07-02801.1993.Peer-Reviewed Original ResearchConceptsPrimary visual cortexSynaptic contactsVisual cortexCortical plateSynaptic densityDendritic spinesPostnatal yearDensity of synapsesThird postnatal monthFirst postnatal yearTime of pubertyMicrons 3Asymmetric synapsesDendritic shaftsLayer VICalcarine fissureCortical neuronsLayer IVPostnatal monthLaminar positionMacaque monkeysFunctional maturationRhesus monkeysAdult levelsNeuropil
1991
Synaptogenesis in Monkey Somatosensory Cortex
Zecevic N, Rakic P. Synaptogenesis in Monkey Somatosensory Cortex. Cerebral Cortex 1991, 1: 510-523. PMID: 1822755, DOI: 10.1093/cercor/1.6.510.Peer-Reviewed Original ResearchConceptsYears of ageSomatosensory cortexSynaptic densityPostcentral gyrusLate fetal ageUpper limb representationDensity of synapsesMonkey somatosensory cortexNumber of synapsesSecond postnatal monthRate of synaptogenesisMicrons 3Timing of synaptogenesisPost-natal lifeSymmetrical synapsesDendritic shaftsSynaptic eliminationSomatosensory functionPostnatal monthDendritic spinesNeocortical areasCortical growthEarly infancyNeurotransmitter receptorsLimb representationGrowth cone distribution patterns in the optic nerve of fetal monkeys: implications for mechanisms of axon guidance
Williams R, Borodkin M, Rakic P. Growth cone distribution patterns in the optic nerve of fetal monkeys: implications for mechanisms of axon guidance. Journal Of Neuroscience 1991, 11: 1081-1094. PMID: 1901353, PMCID: PMC6575387, DOI: 10.1523/jneurosci.11-04-01081.1991.Peer-Reviewed Original ResearchConceptsOptic nervePia materGrowth conesMonkey optic nerveGlial end feetPeripheral gradientFetal monkeysEnd feetAxon ingrowthNerveQuantitative electron microscopic methodsPossible associationOlder axonsDay 39Single fasciclePrenatal developmentTemporal edgeBasal laminaFasciclesAxon guidanceAxonsEarly phaseCell generationMonkeysMaterA novel cytoarchitectonic area induced experimentally within the primate visual cortex.
Rakic P, Suñer I, Williams R. A novel cytoarchitectonic area induced experimentally within the primate visual cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 2083-2087. PMID: 2006147, PMCID: PMC51173, DOI: 10.1073/pnas.88.6.2083.Peer-Reviewed Original ResearchConceptsArea 17Cytoarchitectonic areasVisual cortexSecondary visual cortexPrimary visual cortexPrimate visual cortexAfferent fibersCerebral cortexCortical neuronsThalamic inputsCortical connectionsThalamic fibersCytoarchitectonic regionsCortexCortical parcellationAberrant combinationsArea XProtomap hypothesisCell-cell interactionsNeurons
1990
Axon overproduction and elimination in the corpus callosum of the developing rhesus monkey
LaMantia A, Rakic P. Axon overproduction and elimination in the corpus callosum of the developing rhesus monkey. Journal Of Neuroscience 1990, 10: 2156-2175. PMID: 2376772, PMCID: PMC6570389, DOI: 10.1523/jneurosci.10-07-02156.1990.Peer-Reviewed Original ResearchConceptsCallosal axonsAxon eliminationNewborn monkeysCorpus callosumRhesus monkeysCallosal projection zonePrimate cerebral cortexInterhemispheric projectionsCallosal projectionsCerebral cortexSynaptic densityPostnatal monthPostnatal weekSupernumerary axonsPostnatal eliminationMonkey cortexProjection zonesFetal developmentAdult valuesAxonsLocal proliferationCallosumDay 65BirthMonkeys
1989
Synaptogenesis in visual cortex of normal and preterm monkeys: evidence for intrinsic regulation of synaptic overproduction.
Bourgeois J, Jastreboff P, Rakic P. Synaptogenesis in visual cortex of normal and preterm monkeys: evidence for intrinsic regulation of synaptic overproduction. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 4297-4301. PMID: 2726773, PMCID: PMC287439, DOI: 10.1073/pnas.86.11.4297.Peer-Reviewed Original ResearchConceptsVisual cortexSynaptic overproductionVisual stimulationFirst postnatal monthTime of deliveryAge-matched controlsPrimary visual cortexTime of conceptionControl infantsLaminar distributionPostnatal monthRhesus monkeysCortexQuantitative electron microscopyVisual experienceTime courseSynapsesStimulationMonkeysIntrinsic regulationOverproductionPretermInfantsFetusesWeeks
1984
Development of prestriate visual projections in the monkey and human fetal cerebrum revealed by transient cholinesterase staining
Kostovic I, Rakic P. Development of prestriate visual projections in the monkey and human fetal cerebrum revealed by transient cholinesterase staining. Journal Of Neuroscience 1984, 4: 25-42. PMID: 6693940, PMCID: PMC6564757, DOI: 10.1523/jneurosci.04-01-00025.1984.Peer-Reviewed Original ResearchConceptsPrestriate cortexSubplate zoneCholinesterase stainingChE activityAdjacent neocortical areasPrestriate visual cortexCholinesterase-positive fibersHuman fetal cerebrumNucleus pulvinarisPulvinar inputStage VSubcortical projectionsThalamic nucleiArea 17Fetal brainOccipital lobeNeocortical areasStage IStage IIIStage IVLayer IIIVisual cortexLayer IFetal cerebrumStage II
1983
Overproduction and Elimination of Retinal Axons in the Fetal Rhesus Monkey
Rakic P, Riley K. Overproduction and Elimination of Retinal Axons in the Fetal Rhesus Monkey. Science 1983, 219: 1441-1444. PMID: 6828871, DOI: 10.1126/science.6828871.Peer-Reviewed Original ResearchGeniculo-Cortical Connections in Primates: Normal and Experimentally Altered Development
Rakic P. Geniculo-Cortical Connections in Primates: Normal and Experimentally Altered Development. Progress In Brain Research 1983, 58: 393-404. PMID: 6195694, DOI: 10.1016/s0079-6123(08)60042-4.Peer-Reviewed Original ResearchConceptsVisual cortexDorsal lateral geniculate nucleusFetal rhesus monkeysLateral geniculate nucleusCentral visual pathwaysPrimary visual cortexPrimate visual cortexSynaptic reorganizationCerebral cortexPrenatal mechanismsGeniculate nucleusAfferent connectionsAdult monkeysVisual pathwayRhesus monkeysAnatomical organizationExperimental modelCortexCongenital disorderNormal patternPathological developmentMonkeysColor visionSeries of studiesPrimates
1981
The total number, time of origin and kinetics of proliferation of neurons comprising the deep cerebellar nuclei in the rhesus monkey
Gould B, Rakic P. The total number, time of origin and kinetics of proliferation of neurons comprising the deep cerebellar nuclei in the rhesus monkey. Experimental Brain Research 1981, 44: 195-206. PMID: 7286107, DOI: 10.1007/bf00237341.Peer-Reviewed Original ResearchConceptsCerebellar nucleiPosterior interposed nucleusDeep nucleiSmall neuronsDentate nucleusFastigial nucleusRhesus monkeysInterposed nucleusCessation of neurogenesisGenesis of neuronsPostnatal rhesus monkeysIntermediate time courseDay gestation periodDeep cerebellar nucleiPostnatal ageCerebellar cortexAxonal connectionsOld monkeysNeuron populationsKinetics of proliferationNeuronsAutoradiographic methodTotal numberNeurogenesisPeak of proliferationCoexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis
Levitt P, Cooper M, Rakic P. Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis. Journal Of Neuroscience 1981, 1: 27-39. PMID: 7050307, PMCID: PMC6564162, DOI: 10.1523/jneurosci.01-01-00027.1981.Peer-Reviewed Original ResearchConceptsGlial fibrillary acid proteinLast cell divisionCell divisionRadial glial cellsNeuronal cell lineAcid proteinCerebral ventricular zoneEmbryonic day 80Proliferative zoneGlial precursor cellsMitotic cycleCell typesPeak of neurogenesisPrecursor cellsCell linesVentricular zoneElectron microscopic levelFetal monkeysProliferative cellsGlial cellsSubventricular zoneOccipital lobePhenotypic expressionCytological compositionDistinct classes
1972
Extrinsic cytological determinants of basket and stellate cell dendritic pattern in the cerebellar molecular layer
Rakic P. Extrinsic cytological determinants of basket and stellate cell dendritic pattern in the cerebellar molecular layer. The Journal Of Comparative Neurology 1972, 146: 335-354. PMID: 4628749, DOI: 10.1002/cne.901460304.Peer-Reviewed Original Research
1971
Neuron‐glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electonmicroscopic study in Macacus rhesus
Rakic P. Neuron‐glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electonmicroscopic study in Macacus rhesus. The Journal Of Comparative Neurology 1971, 141: 283-312. PMID: 4101340, DOI: 10.1002/cne.901410303.Peer-Reviewed Original Research
1970
Histogenesis of cortical layers in human cerebellum, particularly the lamina dissecans
Rakic P, Sidman R. Histogenesis of cortical layers in human cerebellum, particularly the lamina dissecans. The Journal Of Comparative Neurology 1970, 139: 473-500. PMID: 4195699, DOI: 10.1002/cne.901390407.Peer-Reviewed Original Research
1969
Telencephalic origin of pulvinar neurons in the fetal human brain
Rakić P, Sidman R. Telencephalic origin of pulvinar neurons in the fetal human brain. Brain Structure And Function 1969, 129: 53-82. PMID: 4186810, DOI: 10.1007/bf00521955.Peer-Reviewed Original ResearchConceptsPulvinar neuronsWeeks of gestationPrevious autoradiographic studiesEnd of gestationRapid Golgi methodFetal human brainSerial horizontal sectionsNumerous proliferating cellsCorpus striatumYoung neuronsLateral ventricleHuman thalamusTelencephalic originThird ventricleNeuron productionSulcus terminalisBipolar cellsGanglionic eminenceAutoradiographic studyPulvinarImmature cellsGolgi methodGestationBrain fragmentsNeurons
1965
MESOCOELIC RECESS IN THE HUMAN BRAIN.
Rakic P. MESOCOELIC RECESS IN THE HUMAN BRAIN. Neurology 1965, 15: 708-15. PMID: 14315293, DOI: 10.1212/wnl.15.8.708.Peer-Reviewed Original Research