2007
4.14 The Development and Evolutionary Expansion of the Cerebral Cortex in Primates
Rakic P, Kornack D. 4.14 The Development and Evolutionary Expansion of the Cerebral Cortex in Primates. 2007, 243-259. DOI: 10.1016/b0-12-370878-8/00004-5.Peer-Reviewed Original ResearchEvolutionary expansionSpecies-specific sizeSmall genetic differencesCerebral cortexEvolutionary mechanismsMammalian speciesBrain evolutionCell cycleCellular eventsSpontaneous mutationsGenetic differencesRadial unit hypothesisRodent embryosBasic organizationModern neurobiologyEmbryosNew insightsNon-human primatesCorticogenesisHuman uniquenessBiological substratesCortexNeuronal interactionsEmbryogenesisHuman cerebrum
2000
Radial Unit Hypothesis of Neocortical Expansion
Rakic P. Radial Unit Hypothesis of Neocortical Expansion. Novartis Foundation Symposia 2000, 228: 30-45. PMID: 10929315, DOI: 10.1002/0470846631.ch3.Peer-Reviewed Original ResearchConceptsRadial unit hypothesisSpecies-specific sizeFamily of genesMutations of genesVentricular zoneMammalian evolutionFounder cellsNatural selectionRegulatory genesCell divisionMorphoregulatory moleculesPostmitotic cellsTransgenic animalsCortical plateCell deathNeocortical expansionGenesBasic organizationGlial scaffoldingColumnar unitsCortical cellsCerebral cortexCellsCortical developmentSynaptic connections
1995
A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution
Rakic P. A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution. Trends In Neurosciences 1995, 18: 383-388. PMID: 7482803, DOI: 10.1016/0166-2236(95)93934-p.Peer-Reviewed Original Research
1991
Critical Cellular Events During Cortical Evolution: Radial Unit Hypothesis
Rakic P. Critical Cellular Events During Cortical Evolution: Radial Unit Hypothesis. NATO Science Series A: 1991, 21-32. DOI: 10.1007/978-1-4899-0652-6_3.Peer-Reviewed Original ResearchCell biological mechanismsCritical cellular eventsComplex cellular changesCellular eventsRadial unit hypothesisCerebral evolutionCortical evolutionCellular mechanismsCellular changesBiological mechanismsRemarkable structureHuman mental capacitiesEvolutionMechanismContemporary neuroscientistsPrimates
1988
Specification of Cerebral Cortical Areas
Rakic P. Specification of Cerebral Cortical Areas. Science 1988, 241: 170-176. PMID: 3291116, DOI: 10.1126/science.3291116.Peer-Reviewed Original ResearchConceptsCytoarchitectonic areasCerebral ventricleEmbryonic cerebral ventriclesCerebral cortical areasHuman cerebral neocortexRadial unit hypothesisNeural transplantsReceptor autoradiographyAfferent inputCerebral neocortexCortical disordersGlial guidesCortical developmentCortical areasEpendymal layerProliferative unitsCell proliferationNeurobiological techniquesVentriclePhenotypic expressionLineage relationshipsCerebral evolutionRetrovirus gene transferGene transferTransplant