Bcl-XL–Caspase-9 Interactions in the Developing Nervous System: Evidence for Multiple Death Pathways
Zaidi A, D'Sa-Eipper C, Brenner J, Kuida K, Zheng T, Flavell R, Rakic P, Roth K. Bcl-XL–Caspase-9 Interactions in the Developing Nervous System: Evidence for Multiple Death Pathways. Journal Of Neuroscience 2001, 21: 169-175. PMID: 11150333, PMCID: PMC6762421, DOI: 10.1523/jneurosci.21-01-00169.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBcl-2-Associated X ProteinBcl-X ProteinCaspase 3Caspase 9CaspasesCells, CulturedCytarabineGanglia, SpinalGenes, LethalHeterozygoteHomozygoteImmunohistochemistryIn Situ Nick-End LabelingLiverMiceMice, KnockoutNervous SystemNeuronsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2TelencephalonTumor Suppressor Protein p53ConceptsGene family membersCaspase-9 deficiencyCaspase-9Telencephalic neural precursor cellsCell deathDouble homozygous mutantsCaspase family membersMultiple death pathwaysNormal nervous system developmentBcl-2Nervous system developmentBax-deficient neuronsNeuronal apoptosisTelencephalic neuronsDeficient embryosNeural precursor cellsDeath pathwaysFamily membersHomozygous mutantsApoptotic pathwayObligate pathwayBcl-xLApoptosis inducersDeficient neuronsTargeted disruptionIndependent parcellation of the embryonic visual cortex and thalamus revealed by combinatorial Eph/ephrin gene expression
Šestan N, Rakic P, Donoghue M. Independent parcellation of the embryonic visual cortex and thalamus revealed by combinatorial Eph/ephrin gene expression. Current Biology 2001, 11: 39-43. PMID: 11166178, DOI: 10.1016/s0960-9822(00)00043-9.Peer-Reviewed Original ResearchConceptsVisual cortical areasVisual cortexCortical plateCortical areasReciprocal connectionsDistinct visual cortical areasLateral geniculate nucleusEphA family membersPulvinar projectionsHigher association areasCytoarchitectonic differentiationThalamic nucleiGeniculate nucleusThalamusAssociation areasThalamocortical systemRhesus monkeysExtrastriate cortexCortexReceptor tyrosine kinasesEph receptor tyrosine kinasesMolecular patternsFamily membersTyrosine kinaseStriateNormal Programmed Cell Death of Developing Avian and Mammalian Neurons Following Inhibition or Genetic Deletion of Caspases
Oppenheim R, Kuan C, Prevette D, Rakic P, Yaginuma H. Normal Programmed Cell Death of Developing Avian and Mammalian Neurons Following Inhibition or Genetic Deletion of Caspases. Research And Perspectives In Neurosciences 2001, 61-74. DOI: 10.1007/978-3-662-04333-2_6.Peer-Reviewed Original ResearchCell deathAbsence of caspasesProgrammed Cell DeathCaspase family membersPost-mitotic neuronsGenetic deletionCaspase inhibitorsCaspase activityNeuronal PCDMammalian neuronsPCDCaspasesChick embryosDeletionFamily membersMorphological degenerationEmbryosUpstreamNeuronsNormal occurrenceInhibitorsOvoInhibitionMembersDeath