2001
Independent parcellation of the embryonic visual cortex and thalamus revealed by combinatorial Eph/ephrin gene expression
Šestan N, Rakic P, Donoghue M. Independent parcellation of the embryonic visual cortex and thalamus revealed by combinatorial Eph/ephrin gene expression. Current Biology 2001, 11: 39-43. PMID: 11166178, DOI: 10.1016/s0960-9822(00)00043-9.Peer-Reviewed Original ResearchConceptsVisual cortical areasVisual cortexCortical plateCortical areasReciprocal connectionsDistinct visual cortical areasLateral geniculate nucleusEphA family membersPulvinar projectionsHigher association areasCytoarchitectonic differentiationThalamic nucleiGeniculate nucleusThalamusAssociation areasThalamocortical systemRhesus monkeysExtrastriate cortexCortexReceptor tyrosine kinasesEph receptor tyrosine kinasesMolecular patternsFamily membersTyrosine kinaseStriate
1999
Molecular Gradients and Compartments in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Gradients and Compartments in the Embryonic Primate Cerebral Cortex. Cerebral Cortex 1999, 9: 586-600. PMID: 10498277, DOI: 10.1093/cercor/9.6.586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntisense Elements (Genetics)Brain ChemistryCloning, MolecularDNA-Binding ProteinsEphrin-A1FemaleGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicHomeodomain ProteinsIn Situ HybridizationMacaca mulattaNeocortexNeuronsPregnancyProsencephalonProteinsReceptor Protein-Tyrosine KinasesTranscription FactorsConceptsCerebral cortexPrimate cerebral cortexEmbryonic cerebral cortexMature cerebral cortexEphA receptor tyrosine kinasesArrival of afferentsPrimate forebrainCortical plateMature cortexEfferent connectionsCortical developmentCortical areasAnteroposterior extentSpecific afferentsMacaque monkeysReceptor tyrosine kinasesPeripheral influencesCortexGene expressionPrimate corticogenesisAfferentsNeocortexIntrinsic programCorticogenesisTyrosine kinase
1994
Synaptic development of the cerebral cortex: implications for learning, memory, and mental illness
Rakic P, Bourgeois J, Goldman-Rakic P. Synaptic development of the cerebral cortex: implications for learning, memory, and mental illness. Progress In Brain Research 1994, 102: 227-243. PMID: 7800815, DOI: 10.1016/s0079-6123(08)60543-9.Peer-Reviewed Original Research
1991
Experimental manipulation of cerebral cortical areas in primates
Rakic P. Experimental manipulation of cerebral cortical areas in primates. Philosophical Transactions Of The Royal Society B Biological Sciences 1991, 331: 291-294. PMID: 1677473, DOI: 10.1098/rstb.1991.0019.Peer-Reviewed Original ResearchConceptsSpecies-specific diversityExperimental manipulationEmbryonic developmentPrimate embryosProtomap hypothesisDevelopmental mechanismsCellular eventsMolecular mechanismsNeuronal phenotypeCerebral cortical areasSynaptic architectureHigher brain functionsCell numberCerebral cortexCongenital disorderExtrinsic influencesSynaptic circuitryCortical areasCytoarchitectonic patternCytoarchitectonic areasBrain functionEmbryosDiversityDistinct areasPhenotype
1989
Regional differences in the distribution of muscarinic cholinergic receptors in the macaque cerebral cortex
Lidow M, Gallager D, Rakic P, Goldman‐Rakic P. Regional differences in the distribution of muscarinic cholinergic receptors in the macaque cerebral cortex. The Journal Of Comparative Neurology 1989, 289: 247-259. PMID: 2808765, DOI: 10.1002/cne.902890206.Peer-Reviewed Original ResearchConceptsM2 receptor subtypeMuscarinic cholinergic receptorsReceptor subtypesCholinergic receptorsM2 receptorsCerebral cortexM1 receptorsLaminar distributionOccipital lobeM1 receptor subtypePopulation of M1Primary motor cortexPrefrontal cortical areasMacaque cerebral cortexCholinergic markersMotor cortexMuscarinic receptorsSupragranular layersLayer IVCortical areasNeocortical areasFrontal lobeCytoarchitectonic areasCortical layersCortical regionsDistribution of neuropeptide y‐containing perikarya and axons in various neocortical areas in the macaque monkey
Kuljis R, Rakic P. Distribution of neuropeptide y‐containing perikarya and axons in various neocortical areas in the macaque monkey. The Journal Of Comparative Neurology 1989, 280: 383-392. PMID: 2918100, DOI: 10.1002/cne.902800305.Peer-Reviewed Original ResearchConceptsNeuropeptide YMacaque monkeysDensity of NPYDistribution of NPYNPY-like immunoreactivityLocal neuronal circuitsLimbic areasInfragranular layersLayer IVArea 17Cortical greyLaminar differencesMotor areaCortical areasNeocortical areasLayers IIPrimary sensoryLaminar segregationWhite matterNeuronal circuitsLayer INPYAxonsImmunocytochemical labelingPerikaryaQuantitative autoradiographic mapping of serotonin 5‐HT1 and 5‐HT2 receptors and uptake sites in the neocortex of the rhesus monkey
Lidow M, Goldman‐Rakic P, Gallager D, Rakic P. Quantitative autoradiographic mapping of serotonin 5‐HT1 and 5‐HT2 receptors and uptake sites in the neocortex of the rhesus monkey. The Journal Of Comparative Neurology 1989, 280: 27-42. PMID: 2918094, DOI: 10.1002/cne.902800104.Peer-Reviewed Original ResearchConceptsLayer IIIReceptor subtypesUptake sitesCortical areasVisual cortexLayer IRhesus monkeysPrimary motor cortexSerotonin uptake sitesQuantitative autoradiographic mappingMonkey cerebral cortexDistribution of serotoninPrimary visual cortexPattern of distributionIVC betaAutoradiographic mappingCerebral cortexMotor cortexLayer IVCortical functionOccipital lobePrimary motorPrestriate cortexReceptor distributionCortex
1988
Quantitative autoradiography of major neurotransmitter receptors in the monkey striate and extrastriate cortex
Rakic P, Goldman-Rakic P, Gallager D. Quantitative autoradiography of major neurotransmitter receptors in the monkey striate and extrastriate cortex. Journal Of Neuroscience 1988, 8: 3670-3690. PMID: 2848104, PMCID: PMC6569589, DOI: 10.1523/jneurosci.08-10-03670.1988.Peer-Reviewed Original ResearchConceptsMajor neurotransmitter receptorsArea 17Neurotransmitter receptorsBmax valuesQuinuclidinyl benzilateCortical layersVisual cortical areasAdult rhesus monkeysExtrinsic afferentsCholinergic receptorsCell-packing densityQuantitative autoradiographyCortical areasLaminar patternSpecific laminaeMonkey striateAdult monkeysArea 18Cytoarchitectonic areasEndogenous neurotransmittersLayer IRhesus monkeysBenzilateAlpha 2ReceptorsSpecification of Cerebral Cortical Areas
Rakic P. Specification of Cerebral Cortical Areas. Science 1988, 241: 170-176. PMID: 3291116, DOI: 10.1126/science.3291116.Peer-Reviewed Original ResearchConceptsCytoarchitectonic areasCerebral ventricleEmbryonic cerebral ventriclesCerebral cortical areasHuman cerebral neocortexRadial unit hypothesisNeural transplantsReceptor autoradiographyAfferent inputCerebral neocortexCortical disordersGlial guidesCortical developmentCortical areasEpendymal layerProliferative unitsCell proliferationNeurobiological techniquesVentriclePhenotypic expressionLineage relationshipsCerebral evolutionRetrovirus gene transferGene transferTransplant