2014
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
Brennand K, Savas J, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont K, Kim H, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao S, Mrksich M, Rakic P, Fang G, Zhang B, Yates J, Gage F. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Molecular Psychiatry 2014, 20: 361-368. PMID: 24686136, PMCID: PMC4182344, DOI: 10.1038/mp.2014.22.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntipsychotic AgentsCell DifferentiationCell MovementCells, CulturedFemaleGene ExpressionHumansMaleMiceMice, Inbred C57BLMice, TransgenicMitochondriaNeural Cell Adhesion MoleculesNeural Stem CellsOxidative StressPhenotypePluripotent Stem CellsProsencephalonProteomicsReactive Oxygen SpeciesSchizophreniaYoung AdultConceptsHiPSC neural progenitor cellsNeural progenitor cellsHuman-induced pluripotent stem cellsHiPSC-derived neuronsGene expressionGene expression comparisonsStable isotope labelingProteomic mass spectrometry analysisAbnormal gene expressionPluripotent stem cellsOxidative stressCytoskeletal remodelingMass spectrometry analysisCellular phenotypesExpression comparisonsDevelopmental mechanismsIsotope labelingPhenotypic differencesBrainSpan AtlasDisease predispositionAmino acidsScalable assayNPC phenotypeStem cellsProgenitor cells
2002
Notch Signaling in the Brain: More than Just a Developmental Story
Šestan N, Rakic P. Notch Signaling in the Brain: More than Just a Developmental Story. Research And Perspectives In Alzheimer's Disease 2002, 19-40. DOI: 10.1007/978-3-642-55996-9_2.Peer-Reviewed Original ResearchNotch signalingNeural developmentCell-cell interaction mechanismCell fate acquisitionCell fate decisionsEarly neural developmentDifferent signaling mechanismsVariety of speciesFate acquisitionNotch signalsCellular phenotypesNotch pathwayMolecular mechanismsSignaling mechanismApoptotic cuesNeuronal differentiationMolecular processesNervous systemAlzheimer's diseaseAdult-onset neurological disordersNeural cellsImportant playersSignalingNeurodegenerative disordersLife span