2001
Caspases and Their Regulation in Apoptosis during Brain Development
Kuan C, Flavell R, Rakic P. Caspases and Their Regulation in Apoptosis during Brain Development. Research And Perspectives In Neurosciences 2001, 75-88. DOI: 10.1007/978-3-662-04333-2_7.Peer-Reviewed Original ResearchJun N-terminal kinasePost-mitotic neuronsMammalian brain developmentCaspase-3 activationCell deathC. elegansCaspase familyDeath gene ced-3Caspase-3Caspase-9Mammalian caspase familyGene ced-3Ectopic cell deathGene ced-9Complex regulation mechanismsNematode C. elegansCell death pathwaysNormal mouse brain developmentN-terminal kinaseBrain developmentCell death cascadeMouse brain developmentCaspase-3 deficiencyCED-3CED-9
2000
Mechanisms of programmed cell death in the developing brain
Kuan C, Roth K, Flavell R, Rakic P, Kuan C, Roth K, Flavell R, Rakic P. Mechanisms of programmed cell death in the developing brain. Trends In Neurosciences 2000, 23: 291-297. PMID: 10856938, DOI: 10.1016/s0166-2236(00)01581-2.Peer-Reviewed Original ResearchConceptsCell deathNematode Caenorhabditis elegansEarly embryonic developmentGene-targeting studiesCell death pathwaysVertebrate nervous systemMammalian brain developmentCaenorhabditis elegansEmbryonic developmentGenetic analysisPostmitotic neuronsBrain developmentNeural cell deathAnalogous functionsDistinct rolesProgenitor cellsMammalian brainApoptosisNew insightsImportant mechanismElegansHomologLater stagesNervous systemMechanismCaspase‐3 is required for apoptosis‐associated DNA fragmentation but not for cell death in neurons deprived of potassium
D'Mello S, Kuan C, Flavell R, Rakic P. Caspase‐3 is required for apoptosis‐associated DNA fragmentation but not for cell death in neurons deprived of potassium. Journal Of Neuroscience Research 2000, 59: 24-31. PMID: 10658182, DOI: 10.1002/(sici)1097-4547(20000101)59:1<24::aid-jnr4>3.0.co;2-8.Peer-Reviewed Original ResearchConceptsCell deathCaspase-3Apoptosis-associated DNA fragmentationDNA fragmentationCell death pathwaysRegulated cell deathPan-caspase inhibitorApoptosis-inducing stimuliDeath pathwaysChromatin condensationCaspase inhibitorsCaspase inhibitionApoptotic featuresCerebellar granule neuronsPotassium deprivationFmkCultured cerebellar granule neuronsCaspasesCrucial effectorNonneuronal cellsApoptosisSame extentGranule neuronsPivotal roleNeuronal death