Unfolded Protein Response Regulation in Keloid Cells
Butler PD, Wang Z, Ly DP, Longaker MT, Koong AC, Yang GP. Unfolded Protein Response Regulation in Keloid Cells. Journal Of Surgical Research 2009, 167: 151-157. PMID: 19631342, PMCID: PMC2888625, DOI: 10.1016/j.jss.2009.04.036.Peer-Reviewed Original ResearchMeSH KeywordsDNA-Binding ProteinsExtracellular MatrixFibroblastsHumansHypoxiaKeloidRegulatory Factor X Transcription FactorsTranscription FactorsUnfolded Protein ResponseWound HealingX-Box Binding Protein 1ConceptsUnfolded protein responsePancreatic ER kinaseXBP-1 proteinNuclear localizationXBP-1Keloid fibroblastsNormal fibroblastsExtracellular matrixXBP-1 splicingUPR transducersSpecific molecular defectsPathologic wound healingUPR responseUPR activationProtein responseER kinaseCellular responsesMolecular defectsATF-6Keloid cellsResponse regulationProteinWound healing therapyWound microenvironmentActivation