Featured Publications
Babesia duncani multi-omics identifies virulence factors and drug targets
Singh P, Lonardi S, Liang Q, Vydyam P, Khabirova E, Fang T, Gihaz S, Thekkiniath J, Munshi M, Abel S, Ciampossin L, Batugedara G, Gupta M, Lu X, Lenz T, Chakravarty S, Cornillot E, Hu Y, Ma W, Gonzalez L, Sánchez S, Estrada K, Sánchez-Flores A, Montero E, Harb O, Le Roch K, Mamoun C. Babesia duncani multi-omics identifies virulence factors and drug targets. Nature Microbiology 2023, 8: 845-859. PMID: 37055610, PMCID: PMC10159843, DOI: 10.1038/s41564-023-01360-8.Peer-Reviewed Original ResearchConceptsDrug targetsVirulence factorsCandidate virulence factorsRNA-seq dataIntraerythrocytic life cycleAttractive drug targetB. duncaniNuclear genomeGenome annotationApicomplexan parasitesApicomplexan pathogensEpigenetic profilesEpigenetic analysisParasite metabolismMalaria-like diseaseHuman erythrocytesLife cycle stagesBabesia speciesGenomeMetabolic requirementsCycle stagesLife cycleBiologySmall moleculesPotent inhibitor
2017
Molecular mechanisms that mediate invasion and egress of malaria parasites from red blood cells
Alaganan A, Singh P, Chitnis C. Molecular mechanisms that mediate invasion and egress of malaria parasites from red blood cells. Current Opinion In Hematology 2017, 24: 208-214. PMID: 28306665, DOI: 10.1097/moh.0000000000000334.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsErythrocytesHost-Parasite InteractionsHumansLife Cycle StagesMalariaMerozoitesPlasmodiumConceptsMalaria parasitesMolecular mechanismsPerforin-like proteinComplex life cycleHost cell invasionDiverse host cellsCurrent understandingDevelopment of inhibitorsDifferent life cycle stagesFemale gametesTimely secretionKey effector moleculesRegulated mannerMolecular basisFemale gametocytesVesicular organellesMosquito midgutFemale anopheline mosquitoesProtein ligandsHost cellsLife cycle stagesCell invasionFunctional roleEffector moleculesParasite growth
2016
Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes
Bargieri D, Thiberge S, Tay C, Carey A, Rantz A, Hischen F, Lorthiois A, Straschil U, Singh P, Singh S, Triglia T, Tsuboi T, Cowman A, Chitnis C, Alano P, Baum J, Pradel G, Lavazec C, Ménard R. Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes. Cell Host & Microbe 2016, 20: 618-630. PMID: 27832590, PMCID: PMC5104695, DOI: 10.1016/j.chom.2016.10.015.Peer-Reviewed Original ResearchConceptsFamily proteinsGamete egressParasite motilityCell invasionErythrocyte invasionMembrane disruptionParasitophorous vacuole membraneMalaria parasite PlasmodiumBlood stage formsApicomplexan parasitesVacuole membraneExtracellular environmentParasite PlasmodiumActomyosin motorParasite transmissionTRAP proteinProteinCell egressStage formsInvasionEgressFalciparum parasitesParasitesIntegral roleMotility