2024
Vitamin B5 metabolism is essential for vacuolar and mitochondrial functions and drug detoxification in fungi
Choi J, Gihaz S, Munshi M, Singh P, Vydyam P, Hamel P, Adams E, Sun X, Khalimonchuk O, Fuller K, Ben Mamoun C. Vitamin B5 metabolism is essential for vacuolar and mitochondrial functions and drug detoxification in fungi. Communications Biology 2024, 7: 894. PMID: 39043829, PMCID: PMC11266677, DOI: 10.1038/s42003-024-06595-7.Peer-Reviewed Original ResearchConceptsSusceptibility of fungiRegulation of genesMetabolism of fatty acidsVacuolar morphologySaccharomyces cerevisiaeAcetyl-CoAEukaryotic pathogensGenetic evidenceGenetic regulationCellular processesAntifungal drugsCo-enzyme ADrug detoxificationAntifungal therapyDrug-resistant strainsFungal infectionsMitochondrial functionFungiAmino acidsAR-12Vitamin B5Synthase activityPathwayExcellent targetGlobal health threat
2016
Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes
Bargieri D, Thiberge S, Tay C, Carey A, Rantz A, Hischen F, Lorthiois A, Straschil U, Singh P, Singh S, Triglia T, Tsuboi T, Cowman A, Chitnis C, Alano P, Baum J, Pradel G, Lavazec C, Ménard R. Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes. Cell Host & Microbe 2016, 20: 618-630. PMID: 27832590, PMCID: PMC5104695, DOI: 10.1016/j.chom.2016.10.015.Peer-Reviewed Original ResearchConceptsFamily proteinsGamete egressParasite motilityCell invasionErythrocyte invasionMembrane disruptionParasitophorous vacuole membraneMalaria parasite PlasmodiumBlood stage formsApicomplexan parasitesVacuole membraneExtracellular environmentParasite PlasmodiumActomyosin motorParasite transmissionTRAP proteinProteinCell egressStage formsInvasionEgressFalciparum parasitesParasitesIntegral roleMotility