2024
Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains
Zhu B, Park J, Coffey S, Russo A, Hsu I, Wang J, Su C, Chang R, Lam T, Gopal P, Ginsberg S, Zhao H, Hafler D, Chandra S, Zhang L. Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains. Science Translational Medicine 2024, 16: eabo1997. PMID: 39475571, DOI: 10.1126/scitranslmed.abo1997.Peer-Reviewed Original ResearchConceptsProteomic analysisAlzheimer's diseasePrefrontal cortexBrain cell typesGenetics of PDParkinson's diseaseCell-cell interactionsChaperone expressionSingle-nucleus transcriptomesExpressed genesTranscriptional changesPostmortem human brainPostmortem brain tissueDiseased brainSynaptic proteinsSingle-cellDown-regulationBrain cell populationsBrain regionsCell typesNeurodegenerative disordersLate-stage PDParkinson's disease brainsDisease etiologyNeuronal vulnerability
2021
Comprehensive Genomic Characterization of A Case of Granular Cell Tumor of the Posterior Pituitary Gland: A Case Report
Hong CS, Elsamadicy AA, Fisayo A, Inzucchi SE, Gopal PP, Vining EM, Erson-Omay EZ, Omay S. Comprehensive Genomic Characterization of A Case of Granular Cell Tumor of the Posterior Pituitary Gland: A Case Report. Frontiers In Endocrinology 2021, 12: 762095. PMID: 34925233, PMCID: PMC8671743, DOI: 10.3389/fendo.2021.762095.Peer-Reviewed Original ResearchConceptsGranular cell tumorPosterior pituitary glandCell tumorsPituitary glandComprehensive genomic characterizationWhole-exome sequencingImmune checkpoint inhibitorsPoor clinical outcomePituitary gland tumorsHistone deacetylase inhibitorsInstitutional review boardRadiographic compressionUnderwent resectionCheckpoint inhibitorsMedical therapyPituitary massClinical outcomesOptic nerveSignificant morbidityResidual diseaseCase reportCentral hypothyroidismPharmacologic agentsGland tumorsTherapeutic targeting
2013
Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression.
Gupta R, Maralani P, Chawla S, Gopal P, Mohan S. Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression. Journal Of Neurosurgery 2013, 120: 522-7. PMID: 24329022, DOI: 10.3171/2013.11.jns13980.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Bacterial AgentsCerebellar DiseasesC-Reactive ProteinDecompression, SurgicalHumansImage Processing, Computer-AssistedImmunohistochemistryInfluenza VaccinesLeukocytosisMagnetic Resonance ImagingMaleNeuroimagingNeurosurgical ProceduresPseudotumor CerebriTomography, X-Ray ComputedVaccinationVentriculostomyConceptsPseudotumoral hemicerebellitisSurgical decompressionBilateral cerebellar hemispheresSignificant mass effectAcute cerebellitisT2 hyperintensityCerebellar swellingPediatric populationRare presentationSurgical interventionElderly malesInflammatory processPial enhancementAdvanced neuroimagingCerebellar hemisphereNeuroimaging findingsMR perfusionHemicerebellitisMR spectroscopyMass effectCerebellitisDecompressionMagnetic resonance