2023
Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS
Guo C, Che X, Briese T, Ranjan A, Allicock O, Yates R, Cheng A, March D, Hornig M, Komaroff A, Levine S, Bateman L, Vernon S, Klimas N, Montoya J, Peterson D, Lipkin W, Williams B. Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS. Cell Host & Microbe 2023, 31: 288-304.e8. PMID: 36758522, PMCID: PMC10183837, DOI: 10.1016/j.chom.2023.01.004.Peer-Reviewed Original ResearchMeSH KeywordsBacteriaButyratesFatigue Syndrome, ChronicGastrointestinal MicrobiomeHumansMetabolomicsConceptsME/CFSFaecalibacterium prausnitziiMyalgic encephalomyelitis/chronic fatigue syndromeFecal short-chain fatty acidsChronic fatigue syndromeShort-chain fatty acidsGut microbiome diversityGut dysbiosisGastrointestinal disturbancesTherapeutic trialsFatigue severityFatigue syndromeOrthostatic intoleranceValidation cohortHealthy controlsCognitive dysfunctionFatigue symptomsGut microbiomeDiverse cohortButyrate producersHuman gutPossible targetsEubacterium rectaleCohortMulti-omics analysis
2018
BacCapSeq: a Platform for Diagnosis and Characterization of Bacterial Infections
Allicock O, Guo C, Uhlemann A, Whittier S, Chauhan L, Garcia J, Price A, Morse S, Mishra N, Briese T, Lipkin W. BacCapSeq: a Platform for Diagnosis and Characterization of Bacterial Infections. MBio 2018, 9: 10.1128/mbio.02007-18. PMID: 30352937, PMCID: PMC6199491, DOI: 10.1128/mbio.02007-18.Peer-Reviewed Original ResearchConceptsHigh-throughput sequencingVirulence Factor DatabaseComprehensive Antibiotic Resistance DatabaseBacterial infectionsResistance genesAntimicrobial resistance genesHealth care costsHuman pathogenic speciesUnbiased high-throughput sequencingAntimicrobial sensitivity profileCharacterization of bacteriaDifferential diagnosisReal-time PCRBlood samplesCare costsCenter databaseTotal readsInappropriate useBacterial readsCapture sequencingBacterial speciesAntimicrobial resistanceVirulence determinantsVirulence factorsFactor database