Novel murine models for studying Cache Valley virus pathogenesis and in utero transmission
López K, Wilson S, Coutermash-Ott S, Tanelus M, Stone W, Porier D, Auguste D, Muller J, Allicock O, Paulson S, Erasmus J, Auguste A. Novel murine models for studying Cache Valley virus pathogenesis and in utero transmission. Emerging Microbes & Infections 2021, 10: 1649-1659. PMID: 34353229, PMCID: PMC8381923, DOI: 10.1080/22221751.2021.1965497.Peer-Reviewed Original ResearchConceptsCache Valley virusMurine modelLong-term therapeutic studiesTissue tropismImmune-competent miceNovel murine modelHighest seropositivity rateInnate immune responseType I interferonCompetent mosquito vectorsSmall animal modelsWide tissue tropismAge-dependent mannerAge-dependent pathogenesisIFN-αβRUtero transmissionSeropositivity rateSpontaneous abortionLethal infectionDisease outcomeVirus pathogenesisImmune responseTherapeutic studiesCongenital malformationsAnimal models