2024
Executive Summary: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE (PEACE) Consensus Conference*
Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J, in collaboration with the Pediatric Acute Lung Injury and Sepsis Investigators Network T. Executive Summary: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE (PEACE) Consensus Conference*. Pediatric Critical Care Medicine 2024, 25: 643-675. PMID: 38959353, PMCID: PMC11216385, DOI: 10.1097/pcc.0000000000003480.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationCritically ill childrenClinical managementClinical management of neonatesManaging extracorporeal membrane oxygenationConsensus statementExpert-based statementsIll childrenCochrane Library (CENTRALManagement of neonatesManagement of anticoagulationCochrane Library databasesExpert consensus statementSystematic reviewPractice statementsMembrane oxygenationNonprocedural bleedingClinical trialsLibrary databasesConsensus conferencePerioperative careRecommendations AssessmentAnticoagulationClinical careGeneral carePriorities for Clinical Research in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation From the Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference
Muszynski J, Bembea M, Gehred A, Lyman E, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Alexander P, Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Himebauch A, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J. Priorities for Clinical Research in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation From the Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e78-e89. PMID: 38959362, PMCID: PMC11216398, DOI: 10.1097/pcc.0000000000003488.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationCritically ill neonatesIll neonatesExtracorporeal membrane oxygenation anticoagulationManagement of extracorporeal membrane oxygenationConsensus conferenceSystematic reviewSystematic review of MEDLINECochrane Library databasesReview of MEDLINECare of neonatesMembrane oxygenationChild Health and Nutrition Research Initiative methodologyHemostasis managementLibrary databasesNeonatesConsensus statementClinical recommendationsAnticoagulationClinical careClinical researchEmbaseCochraneExpert panelPediatric
2023
Efficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis
Aldairi N, Al Ali A, Alabdulqader M, Al Jeraisy M, Cyrus J, Karam O. Efficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis. Cureus 2023, 15: e39967. PMID: 37416033, PMCID: PMC10320736, DOI: 10.7759/cureus.39967.Peer-Reviewed Original ResearchContinuous renal replacement therapyExtracorporeal membrane oxygenationMolecular adsorbent recirculating systemRenal replacement therapyHypotensive eventsCircuit lifespanReplacement therapyAnticoagulation strategiesMeta-analysisThrombotic eventsExtracorporeal supportSystematic reviewAssociated with fewer bleeding eventsControl seriesProportion of bleedingMortality rateCritically ill childrenCritically ill patientsStatistically significant decreaseMultiple electronic databasesRandomized controlled trialsRisk of biasBleeding eventsMembrane oxygenationSupport modalitiesAnticoagulation and hemostasis on extracorporeal membrane oxygenation
Carmona C, Nellis M, Karam O. Anticoagulation and hemostasis on extracorporeal membrane oxygenation. Current Opinion In Pediatrics 2023, 35: 297-302. PMID: 36974451, DOI: 10.1097/mop.0000000000001247.Peer-Reviewed Original ResearchConceptsHemostatic transfusionsMembrane oxygenationPlatelet transfusionsProspective randomized trialsOptimal anticoagulation strategyExtracorporeal membrane oxygenationPlatelet transfusion strategyRecent systematic reviewHemostatic changesAnticoagulation strategiesFrequent complicationMost patientsThrombotic complicationsTransfusion strategyRandomized trialsCareful titrationObservational studyTransfusionSystematic reviewAnticoagulationECMOComplicationsBleedingTwo-fold decreaseRiskCardiac manifestations of multisystem inflammatory syndrome of children after SARS-CoV-2 infection: a systematic review and meta-analysis.
Carmona C, Kuziez M, Freitas C, Cyrus J, Bain J, Karam O. Cardiac manifestations of multisystem inflammatory syndrome of children after SARS-CoV-2 infection: a systematic review and meta-analysis. Cardiology In The Young 2023, 33: 2319-2327. PMID: 36762563, DOI: 10.1017/s104795112300015x.Peer-Reviewed Original ResearchConceptsMultisystem inflammatory syndromeInflammatory syndromeCardiac manifestationsSystematic reviewSARS-CoV-2 infectionCommon cardiac manifestationVentricular systolic dysfunctionSARS-CoV-2 pandemicCoronary abnormalitiesSystolic dysfunctionHospital periodMembrane oxygenationOvid EmbasePatient outcomesOvid MEDLINEChild patientsLarge cohortAccurate prevalenceElectronic searchMortality rateLiterature databasesPrevalenceSyndromeFull textManifestations
2022
Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and Meta-Analysis
Schertz K, Karam O, Demetres M, Mayadunna S, Faraoni D, Nellis ME. Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and Meta-Analysis. Pediatric Critical Care Medicine 2022, 23: e517-e529. PMID: 35997516, DOI: 10.1097/pcc.0000000000003049.Peer-Reviewed Original ResearchConceptsChest tube outputQuality of evidenceCardiopulmonary bypassTranexamic acidCardiac surgeryMean decreaseTube outputPlatelet requirementsPlatelet transfusionsML/P-valueMeta-AnalysisSystematic reviewStandardized data extraction toolBlood product requirementsPediatric cardiac surgeryPlasma requirementsPreferred Reporting ItemsData extraction toolWeb of SciencePostoperative bleedingCyanotic patientsPlasma transfusionBlood lossRBC transfusionAnticoagulation strategies and recurrence of venous thromboembolic events in patients with sickle cell disease: a systematic review and meta-analysis
El-Amin N, Iness A, Cyrus JW, Sisler I, Karam O. Anticoagulation strategies and recurrence of venous thromboembolic events in patients with sickle cell disease: a systematic review and meta-analysis. Annals Of Hematology 2022, 101: 1931-1940. PMID: 35895101, DOI: 10.1007/s00277-022-04901-z.Peer-Reviewed Original ResearchConceptsVenous thromboembolic eventsSickle cell diseaseCell diseaseThromboembolic eventsPulmonary embolismSystematic reviewDevelopment of bleedingOverall bleeding rateVenous thrombotic eventsRisk of mortalityProgression of thrombusAnticoagulant classDifferent anticoagulationAnticoagulation strategiesOverall recurrenceOverall mortalityThrombotic eventsAdverse outcomesPatient populationBleeding rateObservational studyOutcome measuresAppropriate managementPatientsRecurrenceWhat Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding
Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Network A. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Pediatric Critical Care Medicine 2022, 23: e1-e13. PMID: 34989701, PMCID: PMC8769352, DOI: 10.1097/pcc.0000000000002854.Peer-Reviewed Original ResearchConceptsAnemia EXpertise Initiative-Control/AvoidanceIll pediatric patientsIll childrenPlasma transfusionPediatric patientsPlatelet transfusionsConsensus statementSystematic reviewLos Angeles Appropriateness MethodPhysiologic triggerExpert-based statementsCritically Ill ChildrenDevelopment/UniversityExpert consensus statementCochrane Library databasesBleeding expertsRecommendations AssessmentTransfusion managementAppropriateness MethodBlood productsLaboratory testingTransfusionLibrary databasesConsensus conferenceExpert consensusPlasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding
Lieberman L, Karam O, Stanworth SJ, Goobie SM, Crighton G, Goel R, Lacroix J, Nellis ME, Parker RI, Steffen K, Stricker P, Valentine SL, Steiner ME, Network A. Plasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Pediatric Critical Care Medicine 2022, 23: e37-e49. PMID: 34989704, PMCID: PMC8769367, DOI: 10.1097/pcc.0000000000002857.Peer-Reviewed Original ResearchConceptsAnemia EXpertise Initiative-Control/AvoidanceAcute liver diseaseLiver transplantationExpert consensus statementLiver diseaseIntravascular coagulationIll neonatesPlatelet transfusionsIll childrenConsensus statementSystematic reviewLos Angeles Appropriateness MethodExpert-based statementsAcute liver failurePlatelet transfusion strategyDevelopment/UniversityCochrane Library databasesBleeding expertsRecommendations AssessmentTransfusion strategyLiver failureTransfusion managementAppropriateness MethodTransfusionSepsisExecutive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB)
Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Network A. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB). Pediatric Critical Care Medicine 2022, 23: 34-51. PMID: 34989711, PMCID: PMC8820267, DOI: 10.1097/pcc.0000000000002851.Peer-Reviewed Original ResearchConceptsIll pediatric patientsPlatelet transfusionsPediatric patientsIll childrenAnemia EXpertise Initiative-Control/AvoidanceSystematic reviewExpert-based consensusMultidisciplinary international expertsPlatelet transfusion practicesGrading of RecommendationsRisk of bleedingAdministration of plasmaConsensus-based statementsCochrane Library databasesEvidence-based recommendationsBest practice statementsClinical decision treeSubject Headings termsCritical illnessIll infantsTransfusion practicePediatric intensivistsConsensus statementTransfusionLibrary databasesPediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.
Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yehya N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics 2022, 149: s1-s12. PMID: 34970673, PMCID: PMC9599725, DOI: 10.1542/peds.2021-052888b.Peer-Reviewed Original ResearchConceptsMultiple organ dysfunctionOrgan dysfunctionIll childrenElectronic data extraction formSingle organ dysfunctionPrognosis Studies toolRisk of biasImmune system dysfunctionMedical Subject Headings termsEvidence-based criteriaData extraction formSubject Headings termsAcute liverSystem dysfunctionClinical assessmentElectronic searchDysfunctionExtraction formSystematic reviewAvailable evidenceExpert panelMeaningful outcomesStudy identificationChildrenStudy tool
2021
Lung Ultrasound versus Chest X-Ray for the Detection of Fluid Overload in Critically Ill Children: A Systematic Review
Schapka E, Gee J, Cyrus JW, Goldstein G, Greenfield K, Marinello M, Karam O. Lung Ultrasound versus Chest X-Ray for the Detection of Fluid Overload in Critically Ill Children: A Systematic Review. Journal Of Pediatric Intensive Care 2021, 11: 177-182. PMID: 35928036, PMCID: PMC9345674, DOI: 10.1055/s-0041-1725123.Peer-Reviewed Original ResearchChest X-rayFluid overloadLung ultrasoundIll childrenSystematic reviewPerformance of LUSPulmonary fluid overloadPulmonary fluid statusCritically Ill ChildrenQuality of evidenceMultiple electronic databasesCritical illnessCommon complicationVolume overloadClinical burdenFluid statusSensitive modalityEligibility criteriaElectronic databasesFurther evaluationModerate specificityAdult dataGold standardChildrenOverload
2020
Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis
Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion 2020, 36: 501-512. PMID: 32862767, PMCID: PMC8216320, DOI: 10.1177/0267659120952982.Peer-Reviewed Original ResearchConceptsAnticoagulation strategiesMortality rateThrombotic eventsObservational studySystematic reviewProportion of bleedingType of ECMOExtracorporeal membrane oxygenationMultiple electronic databasesLower mortality rateMembrane oxygenationPatientsElectronic databasesECMOThrombosisSignificant differencesXaBleedingReviewMortalityStudySurviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine 2020, 46: 10-67. PMID: 32030529, PMCID: PMC7095013, DOI: 10.1007/s00134-019-05878-6.Peer-Reviewed Original ResearchConceptsSepsis-associated organ dysfunctionOrgan dysfunctionSeptic shockBest practice statementsWeak recommendationKey international meetingsStand-alone meetingManagement of childrenManagement of infectionsQuality of evidenceEvidence-based recommendationsResuscitation of childrenGuideline development processMethodsThe panelInternational expertsRecommendations AssessmentAdjunctive therapyPractice patternsMetabolic therapyConsistent careLarge cohortPanel membersResearch prioritiesInternational guidelinesSystematic reviewSurviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatric Critical Care Medicine 2020, 21: e52-e106. PMID: 32032273, DOI: 10.1097/pcc.0000000000002198.Peer-Reviewed Original ResearchConceptsSepsis-associated organ dysfunctionOrgan dysfunctionSeptic shockBest practice statementsWeak recommendationKey international meetingsStand-alone meetingManagement of childrenQuality of evidenceManagement of infectionsEvidence-based recommendationsGuideline development processResuscitation of childrenInternational expertsRecommendations AssessmentAdjunctive therapyMetabolic therapyPractice patternsConsistent careLarge cohortPanel membersResearch prioritiesSystematic reviewInternational guidelinesDysfunction
2019
Bleeding Scales Applicable to Critically Ill Children: A Systematic Review.
Nellis ME, Levasseur J, Stribling J, Faustino EVS, Zantek ND, Sheth S, Karam O. Bleeding Scales Applicable to Critically Ill Children: A Systematic Review. Pediatric Critical Care Medicine 2019, 20: 603-607. PMID: 30925573, DOI: 10.1097/pcc.0000000000001943.Peer-Reviewed Original ResearchConceptsIll childrenIdiopathic thrombocytopenic purpuraFull-text articlesBleeding scoreBleeding scaleClinical outcomesIll patientsThrombocytopenic purpuraOvid EmbaseCochrane LibraryDatabase inceptionOvid MEDLINEElectronic searchUnique citationsSystematic reviewFinal reviewClinical measurementsOutpatientsInpatientsChildrenAdultsOutcomesBleedingPurpuraHemorrhage
2016
The effect of inhaled nitric oxide in acute respiratory distress syndrome in children and adults: a Cochrane Systematic Review with trial sequential analysis
Karam O, Gebistorf F, Wetterslev J, Afshari A. The effect of inhaled nitric oxide in acute respiratory distress syndrome in children and adults: a Cochrane Systematic Review with trial sequential analysis. Anaesthesia 2016, 72: 106-117. PMID: 27762438, DOI: 10.1111/anae.13628.Peer-Reviewed Original Research