Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats
Iqbal O'Meara AM, Miller Ferguson N, Zven SE, Karam OL, Meyer LC, Bigbee JW, Sato-Bigbee C. Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats. Critical Care Explorations 2020, 2: e0105. PMID: 32426747, PMCID: PMC7188419, DOI: 10.1097/cce.0000000000000105.Peer-Reviewed Original ResearchS100 calcium-binding protein BCalcium-binding protein BGlial fibrillary acidic proteinFibrillary acidic proteinCalcium-binding adaptor molecule 1Adaptor molecule 1Acidic proteinMyelin basic proteinMorphine animalsNeurodevelopmental effectsMolecule-1Intensive care sedationInjection of morphinePotential neurodevelopmental effectsFemale Long-Evans ratsPostnatal day 23Postnatal day 18Novel rodent modelLong-Evans ratsBasic science laboratoryProtein BBasic proteinPICU patientsNeurologic dysfunctionMidazolam administration