2021
Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis
Romano J, Martinez M, Levasseur J, Killinger JS, Karam O, Nellis ME. Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis. Critical Care Explorations 2021, 3: e0572. PMID: 34746797, PMCID: PMC8565795, DOI: 10.1097/cce.0000000000000572.Peer-Reviewed Original ResearchSevere bleedingOncologic diagnosisIll childrenEpidemiology of BleedingPICU-free daysSevere bleeding eventsVentilator-free daysIll pediatric patientsMedian platelet countRetrospective cohort studyInternational normalized ratioBlood component therapyVulnerable patient populationComprehensive cancer centerBleeding eventsHemostatic medicationsPICU admissionPercent patientsTransplant statusCohort studyMedian agePediatric patientsExact epidemiologySevere thrombocytopeniaPlatelet countPerformance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children
Chegondi M, Vijayakumar N, Billa R, Badheka A, Karam O. Performance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children. Journal Of Pediatric Intensive Care 2021, 12: 228-234. PMID: 37565022, PMCID: PMC10411082, DOI: 10.1055/s-0041-1731434.Peer-Reviewed Original ResearchPlatelet mass indexPediatric intensive care unitSeptic shockPICU admissionMass indexPrognostic indicatorFl/Day 1Marker of severityRetrospective observational studyIntensive care unitCare unitPediatric sepsisObservational studyClinical valueDay 3SepsisCharacteristic curveFurther studiesAdmissionPMI valuesChildrenAUCSpecificityNonsurvivors
2020
Association Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass
Klee P, Rimensberger PC, Karam O. Association Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass. Frontiers In Pediatrics 2020, 8: 332. PMID: 32656170, PMCID: PMC7325592, DOI: 10.3389/fped.2020.00332.Peer-Reviewed Original ResearchPediatric critical care unitPICU admissionSystemic oxygen deliveryCardiopulmonary bypassCritical care unitsOxygen extractionBlood glucoseOxygen deliveryCardiac surgeryCare unitLow systemic oxygen deliveryObservational cohort studyDuration of bypassWorse clinical outcomesHigher oxygen extractionLogistic regression modelsCohort studyCardiac lesionsClinical outcomesSurrogate markerPyruvate ratioAdmissionHyperlactatemiaSame timepointsBypass
2019
Anemia at Discharge From the PICU: A Bicenter Descriptive Study.
Demaret P, Valla FV, Behal H, Mimouni Y, Baudelet JB, Karam O, Recher M, Duhamel A, Tucci M, Javouhey E, Leteurtre S. Anemia at Discharge From the PICU: A Bicenter Descriptive Study. Pediatric Critical Care Medicine 2019, 20: e400-e409. PMID: 31246740, DOI: 10.1097/pcc.0000000000002015.Peer-Reviewed Original ResearchConceptsPediatric critical illnessPICU admissionPICU dischargeRisk of anemiaCritical illnessRisk markersHigher C-reactive protein levelsInotropic/vasopressor supportC-reactive protein levelsWorld Health Organization criteriaMedian hemoglobin levelRetrospective cohort studyElectronic medical recordsVasopressor supportPlasma transfusionCohort studyCreatinine levelsMultivariate adjustmentAnemic childrenHemoglobin levelsMechanical ventilationAnemia statusOrganization criteriaMedical recordsIll children
2017
Anemia at pediatric intensive care unit discharge: prevalence and risk markers
Demaret P, Karam O, Tucci M, Lacroix J, Behal H, Duhamel A, Lebrun F, Mulder A, Leteurtre S. Anemia at pediatric intensive care unit discharge: prevalence and risk markers. Annals Of Intensive Care 2017, 7: 107. PMID: 29067568, PMCID: PMC5655401, DOI: 10.1186/s13613-017-0328-8.Peer-Reviewed Original ResearchPICU dischargePICU admissionRisk markersOdds ratioPediatric intensive care unit admissionPediatric intensive care unit dischargeIntensive care unit admissionTertiary care children's hospitalIntensive care unit dischargeCare unit admissionNon-cardiac surgeryPrevalence of anemiaProspective observational studyRisk of anemiaConsequences of anemiaMedian Hb levelStrong risk markerUnit admissionAge-based definitionCritical illnessHospital dischargeMultivariate adjustmentAnemic childrenMedical chartsHemoglobin levels
2016
Ketosis After Cardiopulmonary Bypass in Children Is Associated With an Inadequate Balance Between Oxygen Transport and Consumption*
Klee P, Arni D, Saudan S, Schwitzgebel VM, Sharma R, Karam O, Rimensberger PC. Ketosis After Cardiopulmonary Bypass in Children Is Associated With an Inadequate Balance Between Oxygen Transport and Consumption*. Pediatric Critical Care Medicine 2016, 17: 852-859. PMID: 27472253, DOI: 10.1097/pcc.0000000000000880.Peer-Reviewed Original ResearchConceptsIndependent risk factorPICU admissionCardiopulmonary bypassInsulin treatmentCardiac surgeryRisk factorsPostoperative blood glucose levelsProspective observational studyPatients 6 monthsSubset of patientsSubgroup of patientsVenous oxygen saturationTight glycemic controlBlood glucose levelsGlycemic controlTertiary PICUGlucose intakeWorse outcomesPatient outcomesHigh prevalenceObservational studyGlucose levelsOxygen saturationMetabolic constellationAdmission