2022
Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and Meta-Analysis
Schertz K, Karam O, Demetres M, Mayadunna S, Faraoni D, Nellis ME. Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and Meta-Analysis. Pediatric Critical Care Medicine 2022, 23: e517-e529. PMID: 35997516, DOI: 10.1097/pcc.0000000000003049.Peer-Reviewed Original ResearchConceptsChest tube outputQuality of evidenceCardiopulmonary bypassTranexamic acidCardiac surgeryMean decreaseTube outputPlatelet requirementsPlatelet transfusionsML/P-valueMeta-AnalysisSystematic reviewStandardized data extraction toolBlood product requirementsPediatric cardiac surgeryPlasma requirementsPreferred Reporting ItemsData extraction toolWeb of SciencePostoperative bleedingCyanotic patientsPlasma transfusionBlood lossRBC transfusion
2020
Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines.
Nellis ME, Saini A, Spinella PC, Davis PJ, Steiner ME, Tucci M, Cushing M, Demaret P, Stanworth SJ, Leteurtre S, Karam O. Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines. Pediatric Critical Care Medicine 2020, 21: 267-275. PMID: 31644453, PMCID: PMC7060816, DOI: 10.1097/pcc.0000000000002160.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood TransfusionChildChild, PreschoolExtracorporeal Membrane OxygenationFemaleHemorrhageHumansInfantInfant, NewbornIntensive Care Units, PediatricInternational Normalized RatioMalePlasmaPlatelet CountPlatelet TransfusionPractice Guidelines as TopicProspective StudiesSurveys and QuestionnairesConceptsExtracorporeal membrane oxygenationMembrane oxygenationPlatelet transfusionsTotal platelet countPlasma transfusionPlatelet countSubgroup analysisInstitutional protocolMedian increaseInternational point prevalence studyPediatric extracorporeal membrane oxygenationTotal median doseInternational normalized ratioML/Point prevalence studyPlatelet count valuesScreening weekMedian doseMild coagulopathyNormalized ratioInterventional studyLocal guidelinesObservational studyMedian reductionTransfusion
2019
Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome.
Nellis ME, Dalton H, Karam O. Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome. Critical Care Medicine 2019, 47: e886-e892. PMID: 31449061, PMCID: PMC8608374, DOI: 10.1097/ccm.0000000000003968.Peer-Reviewed Original ResearchConceptsChest tube bleedingExtracorporeal membrane oxygenationCollaborative Pediatric Critical Care Research NetworkMembrane oxygenationChest tubeClinical outcomesPlatelet countML/Large observational cohort studyEunice Kennedy Shriver National InstituteCritical Care Research NetworkPICU-free daysPercent of patientsObservational cohort studyWorse clinical outcomesHuman Development Collaborative Pediatric Critical Care Research NetworkMembrane oxygenation specialistsHospital mortalityTransfusion volumeCohort studyHeparin doseConsecutive patientsThrombotic eventsPediatric institutionHemostatic testsCriteria for Clinically Relevant Bleeding in Critically Ill Children
Karam O, Nellis ME, Zantek ND, Lacroix J, Faustino EVS. Criteria for Clinically Relevant Bleeding in Critically Ill Children. Pediatric Critical Care Medicine 2019, Publish Ahead of Print: &na;. PMID: 30575698, DOI: 10.1097/pcc.0000000000001828.Peer-Reviewed Original ResearchConceptsRelevant bleedingStreaks of bloodIll childrenEndotracheal tubeClinical relevancePediatric critical care physiciansClinically Relevant BleedingML/Critical care physiciansCritical illnessIll adultsOrgan failureCare physiciansGastric tubeClinical significanceNurse practitionersBleedingDiagnostic criteriaClinical practiceResponse rateIntensivists' perceptionWeb-based surveyDiagnostic definitionRespondents' geographical locationBlood