Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion*
Yu D, Qu C, Henegariu O, Lu X, Feng G. Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion*. Journal Of Biological Chemistry 1998, 273: 21125-21131. PMID: 9694867, DOI: 10.1074/jbc.273.33.21125.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionCell Adhesion MoleculesCell LineCell MovementCytoskeletal ProteinsFibroblastsFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesHeterozygoteHomozygoteIntracellular Signaling Peptides and ProteinsMicePaxillinPhenotypePhosphoproteinsProtein Tyrosine Phosphatase, Non-Receptor Type 11Protein Tyrosine Phosphatase, Non-Receptor Type 6Protein Tyrosine PhosphatasesProtein-Tyrosine KinasesSH2 Domain-Containing Protein Tyrosine PhosphatasesConceptsShp-2 mutant cellsMutant cellsFocal adhesionsSHP-2Tyrosine phosphataseProtein tyrosine phosphatase SHP-2SHP-2 tyrosine phosphataseCell spreadingFunctional SHP-2SHP-2 mutationsPhosphatase SHP-2Cytoplasmic tyrosine phosphataseF-actin aggregationWild-type cellsFocal adhesion kinaseMesodermal patterningSH2 domainFAK dephosphorylationCytoskeletal architectureSrc SH2Adhesion kinaseSignal relayCell peripheryGrowth factor receptorCell motility