Chromosome instability contributes to loss of heterozygosity in mice lacking p53
Shao C, Deng L, Henegariu O, Liang L, Stambrook P, Tischfield J. Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 7405-7410. PMID: 10861008, PMCID: PMC16558, DOI: 10.1073/pnas.97.13.7405.Peer-Reviewed Original ResearchConceptsGenetic instabilityChromosome instabilityP53-null miceP53 tumor suppressor proteinMultiple cellular processesCell cycle checkpointsTumor suppressor proteinSomatic cell variantsNormal cellsNull miceCellular processesCycle checkpointsGenetic variationMitotic recombinationSuppressor proteinEpigenetic alterationsInterstitial deletionLOH eventsCell deathLoss of heterozygosityP53 functionFibroblast coloniesPoint mutationsFunctional p53Tumor initiation