Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury
Sung E, Park M, Henegariu O, Sime P, Chae W. Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury. American Journal Of Pathology 2023, 193: 1130-1142. PMID: 37263344, PMCID: PMC10477954, DOI: 10.1016/j.ajpath.2023.05.009.Peer-Reviewed Original ResearchConceptsLung injuryImmune cell infiltrationLung inflammationCell infiltrationCollagen depositionBleomycin-Induced Lung InjuryOrchestration of inflammationRole of DKK1Patient's lung tissueSmooth muscle actinGrowth factor-β1Myofibroblast marker αDKK1 protein expressionTissue repair processAntibody administrationPulmonary inflammationPulmonary fibrosisProfibrotic cytokinesDKK1 levelsAttractive molecular targetFibrosis modelLung tissueTissue injuryTissue fibrosisFactor-β1