Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice
Shao C, Deng L, Henegariu O, Liang L, Raikwar N, Sahota A, Stambrook P, Tischfield J. Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 9230-9235. PMID: 10430925, PMCID: PMC17762, DOI: 10.1073/pnas.96.16.9230.Peer-Reviewed Original ResearchMeSH KeywordsAdenine PhosphoribosyltransferaseAnimalsChromosome MappingCrosses, GeneticEar, ExternalExonsFemaleFibroblastsGenes, RecessiveGenetic VariationHeterozygoteHumansLoss of HeterozygosityMaleMiceMice, Inbred C3HMice, Inbred StrainsMice, Mutant StrainsMutagenesisPoint MutationRecombination, GeneticSkinT-LymphocytesConceptsMitotic recombinationPolymorphic molecular markersSomatic cell variantsProgeny of crossesFrequency of crossoversHigh spontaneous frequencyAPRT enzyme activitySomatic mutagenesisMap distanceCytological markersSelection mediumHuman peripheral T cellsMolecular markersChromosome 8Vivo lossCell coloniesAPRTEnzyme activityNormal fibroblastsRecombinationHeterozygous micePeripheral T cellsAdenine analogueHeterozygote miceVivo