2016
Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells
Boddupalli CS, Bar N, Kadaveru K, Krauthammer M, Pornputtapong N, Mai Z, Ariyan S, Narayan D, Kluger H, Deng Y, Verma R, Das R, Bacchiocchi A, Halaban R, Sznol M, Dhodapkar MV, Dhodapkar KM. Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells. JCI Insight 2016, 1: e88955. PMID: 28018970, PMCID: PMC5161225, DOI: 10.1172/jci.insight.88955.Peer-Reviewed Original ResearchTumor-infiltrating lymphocytesMemory T cellsTissue-resident memory T cellsT cell receptorImmune checkpointsT cellsIndividual metastasesSubset of TILsExpression of ICsCell receptorTumor cellsLess IL-2Blood T cellsExpression of VEGFTIL infiltrationDurable responsesAdvanced melanomaImmune therapyNeoantigen loadIL-2Immune cellsNonlymphoid tissuesSame patientMyeloid cellsMetastasis
2015
Tissue resident memory T cells create genetically distinct immune microenvironments within melanoma metastasis
Dhodapkar K, Bar N, Boddupalli C, Kadaveru K, Mai Z, Deng Y, Sznol M, Dhodapkar M. Tissue resident memory T cells create genetically distinct immune microenvironments within melanoma metastasis. Journal For ImmunoTherapy Of Cancer 2015, 3: o15. PMCID: PMC4645446, DOI: 10.1186/2051-1426-3-s2-o15.Peer-Reviewed Original Research