2024
Pitfalls of PRAME Immunohistochemistry in a Large Series of Melanocytic and Nonmelanocytic Lesions With Literature Review
Turner N, Ko C, McNiff J, Galan A. Pitfalls of PRAME Immunohistochemistry in a Large Series of Melanocytic and Nonmelanocytic Lesions With Literature Review. American Journal Of Dermatopathology 2024, 46: 21-30. PMID: 37982498, DOI: 10.1097/dad.0000000000002584.Peer-Reviewed Original ResearchConceptsConventional malignant melanomaMalignant melanomaPRAME immunohistochemistryBorderline lesionsNonmelanocytic lesionsDysplastic neviAmerican Joint CommitteePathological tumor stageMalignant melanocytic proliferationsBanal melanocytic nevusUlceration statusInstitution experienceBreslow depthMean ageTumor stageClinicopathologic correlationConsecutive casesMale genderAtypical fibroxanthomaSevere atypiaJoint CommitteeLarge seriesAmbiguous melanocytic lesionsMelanocytic proliferationMalignant counterparts
2023
Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance.
Krykbaeva I, Bridges K, Damsky W, Pizzurro G, Alexander A, McGeary M, Park K, Muthusamy V, Eyles J, Luheshi N, Turner N, Weiss S, Olino K, Kaech S, Kluger H, Miller-Jensen K, Bosenberg M. Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance. Cancer Immunology Research 2023, 11: 1332-1350. PMID: 37478171, DOI: 10.1158/2326-6066.cir-22-0699.Peer-Reviewed Original ResearchConceptsPD-1 resistanceDendritic cellsTumor regressionAnti-PD-1 resistanceActivates Dendritic CellsCytokine secretion profilingSystemic cytokine profileTriple therapy combinationInnate immune activationAdaptive immune responsesComplete tumor regressionMajority of miceSignificant clinical challengeMouse melanoma modelT cell activationAgonistic CD40Checkpoint inhibitorsDC subsetsTriple therapyCytokine profileImmune activationCombinatorial immunotherapyTherapy combinationsT cellsClinical challenge
2022
Facial hyperpigmentation and crusted papules on the hands.
Leasure AC, Turner N, Lim I. Facial hyperpigmentation and crusted papules on the hands. JAAD Case Reports 2022, 20: 23-25. PMID: 35036499, PMCID: PMC8753054, DOI: 10.1016/j.jdcr.2021.09.043.Peer-Reviewed Original Research
2021
Subepidermal blistering eruptions, including bullous pemphigoid, following COVID-19 vaccination
Tomayko MM, Damsky W, Fathy R, McMahon DE, Turner N, Valentin MN, Rallis T, Aivaz O, Fox LP, Freeman EE. Subepidermal blistering eruptions, including bullous pemphigoid, following COVID-19 vaccination. Journal Of Allergy And Clinical Immunology 2021, 148: 750-751. PMID: 34275656, PMCID: PMC8280592, DOI: 10.1016/j.jaci.2021.06.026.Peer-Reviewed Original Research
2020
Recurrent cutaneous Exophiala phaeohyphomycosis in an immunosuppressed patient.
Turner N, Kibbi N, Panse G, Imaeda S. Recurrent cutaneous Exophiala phaeohyphomycosis in an immunosuppressed patient. Cutis 2020, 106: e7-e8. PMID: 33465199, DOI: 10.12788/cutis.0120.Peer-Reviewed Case Reports and Technical Notes
2019
LB1122 Myeloid targeting in combination with PD1 inhibition boosts anti-tumor immunity in melanoma
Krykbaeva I, Damsky W, Turner N, Perry C, Kluger H, Bosenberg M. LB1122 Myeloid targeting in combination with PD1 inhibition boosts anti-tumor immunity in melanoma. Journal Of Investigative Dermatology 2019, 139: b19. DOI: 10.1016/j.jid.2019.06.089.Peer-Reviewed Original ResearchB cell depletion or absence does not impede anti-tumor activity of PD-1 inhibitors
Damsky W, Jilaveanu L, Turner N, Perry C, Zito C, Tomayko M, Leventhal J, Herold K, Meffre E, Bosenberg M, Kluger HM. B cell depletion or absence does not impede anti-tumor activity of PD-1 inhibitors. Journal For ImmunoTherapy Of Cancer 2019, 7: 153. PMID: 31200747, PMCID: PMC6567557, DOI: 10.1186/s40425-019-0613-1.Peer-Reviewed Original ResearchConceptsPD-1 inhibitorsB cell contentB-cell depletionAnti-tumor activityB cellsMuMT miceCell depletionAnti-PD-1 inhibitorsAnti-PD-1 responseB-cell depleting drugsTumor-infiltrating B cellsImpaired B-cell functionT cell-dependent tumor rejectionPD-1 inhibitionMC38 colon cancerB cell functionAnti-tumor effectsB-cell malignanciesMurine cancer modelsCell contentOverall survivalTumor rejectionCD20 antibodyAutoimmune disordersTumor shrinkage
2018
Atezolizumab‐associated vitiligo‐like leukoderma in a patient with transitional cell carcinoma
Turner N, Leventhal J. Atezolizumab‐associated vitiligo‐like leukoderma in a patient with transitional cell carcinoma. International Journal Of Dermatology 2018, 57: e90-e92. PMID: 30091457, DOI: 10.1111/ijd.14191.Peer-Reviewed Original ResearchGenetics of metastasis: melanoma and other cancers
Turner N, Ware O, Bosenberg M. Genetics of metastasis: melanoma and other cancers. Clinical & Experimental Metastasis 2018, 35: 379-391. PMID: 29722002, DOI: 10.1007/s10585-018-9893-y.Peer-Reviewed Original Research1245 PD-1 blockade impedes tumor growth in the immunogenic YUMMER1.7 mouse melanoma model
Turner N, Damsky W, Wang J, Meeth K, Blenman K, Bosenberg M. 1245 PD-1 blockade impedes tumor growth in the immunogenic YUMMER1.7 mouse melanoma model. Journal Of Investigative Dermatology 2018, 138: s211. DOI: 10.1016/j.jid.2018.03.1260.Peer-Reviewed Original Research