2023
Improving Early Colostrum Administration to Very Low Birth Weight Infants in a Level 3 Neonatal Intensive Care Unit: A Quality Improvement Initiative
Fleiss N, Morrison C, Nascimento A, Stone D, Myers E. Improving Early Colostrum Administration to Very Low Birth Weight Infants in a Level 3 Neonatal Intensive Care Unit: A Quality Improvement Initiative. The Journal Of Pediatrics 2023, 260: 113421. PMID: 37076038, DOI: 10.1016/j.jpeds.2023.113421.Peer-Reviewed Original ResearchConceptsLevel 3 neonatal intensive care unitNeonatal intensive care unitIntensive care unitOral immune therapyQuality improvement initiativesCare unitVLBW infantsOutcome measuresHuman milkLow birth weight infantsMultidisciplinary quality improvement initiativeBirth weight infantsSecondary outcome measuresElectronic health record usePrimary outcome measureLow birthweight infantsImprovement initiativesHealthcare Improvement's ModelWeight infantsOIT protocolImmune therapyBirthweight infantsColostrum administrationSignificant improvementBaseline mean
2022
Sequential organ failure assessment scores to predict outcomes: from adults to neonates
Fleiss N, Polin R. Sequential organ failure assessment scores to predict outcomes: from adults to neonates. Current Opinion In Pediatrics 2022, 35: 218-222. PMID: 36449658, DOI: 10.1097/mop.0000000000001207.Peer-Reviewed Original ResearchConceptsSepsis-attributable mortalityNeonatal sepsisSOFA scoreAttributable mortalityPediatric populationSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreLow birth weight infantsNeonatal disease statesBirth weight infantsRisk of mortalityPatient safety outcomesSepsis definitionsWeight infantsPreterm infantsOrgan dysfunctionPrognostic utilityRisk stratificationClinical progressionAdverse outcomesPatient cohortLaboratory criteriaSeverity scoreSafety outcomesSepsisWhat’s new in the management of neonatal early-onset sepsis?
Fleiss N, Schwabenbauer K, Randis TM, Polin RA. What’s new in the management of neonatal early-onset sepsis? Archives Of Disease In Childhood - Fetal And Neonatal Edition 2022, 108: 10-14. PMID: 35618407, DOI: 10.1136/archdischild-2021-323532.Peer-Reviewed Original Research
2021
Can we back off using antibiotics in the NICU?
Fleiss N, Hooven TA, Polin RA. Can we back off using antibiotics in the NICU? Seminars In Fetal And Neonatal Medicine 2021, 26: 101217. PMID: 33678550, DOI: 10.1016/j.siny.2021.101217.Peer-Reviewed Original ResearchConceptsMulti-drug resistant organismsLong-term adverse effectsCulture-positive sepsisAntibiotic prescribing practicesDelaying antibioticsNeonatal sepsisPositive sepsisPrescribing practicesAntibiotic utilizationNeonatal ICUAntibiotic stewardshipAntibiotic useAntibiotic overuseResistant organismsAdverse effectsAntibioticsSepsisNICUInfantsLaboratory testingICUNeonatesSpecified intervalsNeonatologistsClinical and vital sign changes associated with late-onset sepsis in very low birth weight infants at 3 NICUs.
Sullivan BA, Nagraj VP, Berry KL, Fleiss N, Rambhia A, Kumar R, Wallman-Stokes A, Vesoulis ZA, Sahni R, Ratcliffe S, Lake DE, Moorman JR, Fairchild KD. Clinical and vital sign changes associated with late-onset sepsis in very low birth weight infants at 3 NICUs. Journal Of Neonatal-Perinatal Medicine 2021, 14: 553-561. PMID: 33523025, PMCID: PMC8316489, DOI: 10.3233/npm-200578.Peer-Reviewed Original ResearchConceptsLate-onset sepsisLow birth weight infantsBirth weight infantsClinical signsWeight infantsHeart rateBaseline risk factorsVital sign changesNon-infectious conditionsAbnormal CBCFirst sepsisAbdominal distensionVLBW infantsCentral cathetersMechanical ventilationPremature infantsPostnatal ageBaseline variablesClinician documentationRisk factorsClinical changesSepsisInfantsVital signsLogistic regression