2023
Improving Early Colostrum Administration to Very Low Birth Weight Infants in a Level 3 Neonatal Intensive Care Unit: A Quality Improvement Initiative
Fleiss N, Morrison C, Nascimento A, Stone D, Myers E. Improving Early Colostrum Administration to Very Low Birth Weight Infants in a Level 3 Neonatal Intensive Care Unit: A Quality Improvement Initiative. The Journal Of Pediatrics 2023, 260: 113421. PMID: 37076038, DOI: 10.1016/j.jpeds.2023.113421.Peer-Reviewed Original ResearchMeSH KeywordsBreast FeedingColostrumFemaleHumansInfantInfant, NewbornInfant, Very Low Birth WeightIntensive Care Units, NeonatalMilk, HumanPregnancyQuality ImprovementConceptsLevel 3 neonatal intensive care unitNeonatal intensive care unitIntensive care unitOral immune therapyQuality improvement initiativesCare unitVLBW infantsOutcome measuresHuman milkLow birth weight infantsMultidisciplinary quality improvement initiativeBirth weight infantsSecondary outcome measuresElectronic health record usePrimary outcome measureLow birthweight infantsImprovement initiativesHealthcare Improvement's ModelWeight infantsOIT protocolImmune therapyBirthweight infantsColostrum administrationSignificant improvementBaseline mean
2022
Infection prevention for extremely low birth weight infants in the NICU
Fleiss N, Tarun S, Polin RA. Infection prevention for extremely low birth weight infants in the NICU. Seminars In Fetal And Neonatal Medicine 2022, 27: 101345. PMID: 35550785, PMCID: PMC9006400, DOI: 10.1016/j.siny.2022.101345.Peer-Reviewed Original ResearchMeSH KeywordsCOVID-19Enterocolitis, NecrotizingHumansInfant, Extremely Low Birth WeightInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightIntensive Care Units, NeonatalSARS-CoV-2ConceptsInfection preventionLow birth weight infantsEarly antibiotic exposureBirth weight infantsHuman milk feedingPreterm newborn infantsSARS-CoV-2 global pandemicUse of probioticsAntifungal prophylaxisEnteral feedingWeight infantsPreterm infantsProlonged hospitalizationEvidence-based practiceMilk feedingNewborn infantsAntibiotic exposureInvasive interventionsSystemic infectionImmune defenseInfantsInfectionPreventionSuch interventionsNICU
2021
Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection
Fleiss N, Coggins SA, Lewis AN, Zeigler A, Cooksey KE, Walker LA, Husain AN, de Jong BS, Wallman-Stokes A, Alrifai MW, Visser DH, Good M, Sullivan B, Polin RA, Martin CR, Wynn JL. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection. JAMA Network Open 2021, 4: e2036518. PMID: 33538825, PMCID: PMC7862993, DOI: 10.1001/jamanetworkopen.2020.36518.Peer-Reviewed Original ResearchMeSH KeywordsBacteremiaCatheter-Related InfectionsFemaleFungemiaGestational AgeGram-Negative Bacterial InfectionsGram-Positive Bacterial InfectionsHospital MortalityHumansInfant, Extremely Low Birth WeightInfant, Extremely PrematureInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightIntensive Care Units, NeonatalIntestinal PerforationMaleNeonatal SepsisOrgan Dysfunction ScoresPeritonitisPrognosisRisk AssessmentConceptsSequential Organ Failure AssessmentInfection-related mortalityLate-onset infectionOrgan Failure AssessmentPreterm infantsMortality riskConsensus definitionAcademic neonatal intensive care unitMulticenter retrospective cohort studyNeonatal intensive care unitMedian birth weightRetrospective cohort studyMedian gestational ageIntensive care unitCharacteristic curveFailure AssessmentTime of evaluationWeight infantsCohort studyOnset infectionPrimary outcomeTotal cohortCare unitGestational ageBirth weightClinical and vital sign changes associated with late-onset sepsis in very low birth weight infants at 3 NICUs.
Sullivan BA, Nagraj VP, Berry KL, Fleiss N, Rambhia A, Kumar R, Wallman-Stokes A, Vesoulis ZA, Sahni R, Ratcliffe S, Lake DE, Moorman JR, Fairchild KD. Clinical and vital sign changes associated with late-onset sepsis in very low birth weight infants at 3 NICUs. Journal Of Neonatal-Perinatal Medicine 2021, 14: 553-561. PMID: 33523025, PMCID: PMC8316489, DOI: 10.3233/npm-200578.Peer-Reviewed Original ResearchMeSH KeywordsHumansInfantInfant, NewbornInfant, Very Low Birth WeightIntensive Care Units, NeonatalOxygen SaturationRisk FactorsSepsisVital SignsConceptsLate-onset sepsisLow birth weight infantsBirth weight infantsClinical signsWeight infantsHeart rateBaseline risk factorsVital sign changesNon-infectious conditionsAbnormal CBCFirst sepsisAbdominal distensionVLBW infantsCentral cathetersMechanical ventilationPremature infantsPostnatal ageBaseline variablesClinician documentationRisk factorsClinical changesSepsisInfantsVital signsLogistic regression