2022
Sequential organ failure assessment scores to predict outcomes: from adults to neonates
Fleiss N, Polin R. Sequential organ failure assessment scores to predict outcomes: from adults to neonates. Current Opinion In Pediatrics 2022, 35: 218-222. PMID: 36449658, DOI: 10.1097/mop.0000000000001207.Peer-Reviewed Original ResearchConceptsSepsis-attributable mortalityNeonatal sepsisSOFA scoreAttributable mortalityPediatric populationSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreLow birth weight infantsNeonatal disease statesBirth weight infantsRisk of mortalityPatient safety outcomesSepsis definitionsWeight infantsPreterm infantsOrgan dysfunctionPrognostic utilityRisk stratificationClinical progressionAdverse outcomesPatient cohortLaboratory criteriaSeverity scoreSafety outcomesSepsisInfection prevention for extremely low birth weight infants in the NICU
Fleiss N, Tarun S, Polin RA. Infection prevention for extremely low birth weight infants in the NICU. Seminars In Fetal And Neonatal Medicine 2022, 27: 101345. PMID: 35550785, PMCID: PMC9006400, DOI: 10.1016/j.siny.2022.101345.Peer-Reviewed Original ResearchConceptsInfection preventionLow birth weight infantsEarly antibiotic exposureBirth weight infantsHuman milk feedingPreterm newborn infantsSARS-CoV-2 global pandemicUse of probioticsAntifungal prophylaxisEnteral feedingWeight infantsPreterm infantsProlonged hospitalizationEvidence-based practiceMilk feedingNewborn infantsAntibiotic exposureInvasive interventionsSystemic infectionImmune defenseInfantsInfectionPreventionSuch interventionsNICU
2021
Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection
Fleiss N, Coggins SA, Lewis AN, Zeigler A, Cooksey KE, Walker LA, Husain AN, de Jong BS, Wallman-Stokes A, Alrifai MW, Visser DH, Good M, Sullivan B, Polin RA, Martin CR, Wynn JL. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection. JAMA Network Open 2021, 4: e2036518. PMID: 33538825, PMCID: PMC7862993, DOI: 10.1001/jamanetworkopen.2020.36518.Peer-Reviewed Original ResearchMeSH KeywordsBacteremiaCatheter-Related InfectionsFemaleFungemiaGestational AgeGram-Negative Bacterial InfectionsGram-Positive Bacterial InfectionsHospital MortalityHumansInfant, Extremely Low Birth WeightInfant, Extremely PrematureInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightIntensive Care Units, NeonatalIntestinal PerforationMaleNeonatal SepsisOrgan Dysfunction ScoresPeritonitisPrognosisRisk AssessmentConceptsSequential Organ Failure AssessmentInfection-related mortalityLate-onset infectionOrgan Failure AssessmentPreterm infantsMortality riskConsensus definitionAcademic neonatal intensive care unitMulticenter retrospective cohort studyNeonatal intensive care unitMedian birth weightRetrospective cohort studyMedian gestational ageIntensive care unitCharacteristic curveFailure AssessmentTime of evaluationWeight infantsCohort studyOnset infectionPrimary outcomeTotal cohortCare unitGestational ageBirth weight