Noa Fleiss, MD, MPH
Assistant Professor of PediatricsCards
About
Titles
Assistant Professor of Pediatrics
Director of Quality Improvement for Neonatal-Perinatal Medicine, Pediatrics
Biography
Noa Fleiss joined the Yale Neonatal-Perinatal Medicine faculty in 2020 as an Assistant Professor of Pediatrics, after completing her Neonatology Fellowship and Pediatric Residency at New York Presbyterian - Columbia University. Dr. Fleiss serves as the Director of Quality Improvement for the Yale New Haven Children’s Hospital NICU, leading several projects focused on non-invasive respiratory care, infection prevention, and maternal mental health. She is the co-director of the Quality Improvement Pediatric Residency curriculum and is a mentor to trainees interested in improvement work. Her clinical research interest is in neonatal infectious diseases, specifically the diagnosis and management of neonatal sepsis.
Appointments
Neonatal-Perinatal Medicine
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Fellowship
- New York Presbyterian Columbia University Medical Center (2020)
- Residency
- New York Presbyterian Columbia University Medical Center (2017)
- MD
- Tufts University School of Medicine (2014)
- MPH
- George Washington University Medical Center (2010)
Research
Publications
2024
The diagnostic utility of obtaining two blood cultures for the diagnosis of early onset sepsis in neonates
Fleiss N, Shabanova V, Murray T, Gallagher P, Bizzarro M. The diagnostic utility of obtaining two blood cultures for the diagnosis of early onset sepsis in neonates. Journal Of Perinatology 2024, 44: 745-747. PMID: 38409330, DOI: 10.1038/s41372-024-01914-6.Peer-Reviewed Original Research
2023
Improving Early Colostrum Administration to Very Low Birth Weight Infants in a Level 3 Neonatal Intensive Care Unit: A Quality Improvement Initiative
Fleiss N, Morrison C, Nascimento A, Stone D, Myers E. Improving Early Colostrum Administration to Very Low Birth Weight Infants in a Level 3 Neonatal Intensive Care Unit: A Quality Improvement Initiative. The Journal Of Pediatrics 2023, 260: 113421. PMID: 37076038, DOI: 10.1016/j.jpeds.2023.113421.Peer-Reviewed Original ResearchConceptsLevel 3 neonatal intensive care unitNeonatal intensive care unitIntensive care unitOral immune therapyQuality improvement initiativesCare unitVLBW infantsOutcome measuresHuman milkLow birth weight infantsMultidisciplinary quality improvement initiativeBirth weight infantsSecondary outcome measuresElectronic health record usePrimary outcome measureLow birthweight infantsImprovement initiativesHealthcare Improvement's ModelWeight infantsOIT protocolImmune therapyBirthweight infantsColostrum administrationSignificant improvementBaseline meanShort course antibiotic therapy: When is no difference the same?
Fleiss N, Gurka M, Burchfield D. Short course antibiotic therapy: When is no difference the same? Journal Of Perinatology 2023, 43: 683-684. PMID: 37029166, DOI: 10.1038/s41372-023-01671-y.Peer-Reviewed Original ResearchReducing MRSA Infection in a New NICU During the COVID-19 Pandemic.
Barrett R, Fleiss N, Hansen C, Campbell M, Rychalsky M, Murdzek C, Krechevsky K, Abbott M, Allegra T, Blazevich B, Dunphy L, Fox A, Gambardella T, Garcia L, Grimm N, Scoffone A, Bizzarro M, Murray T. Reducing MRSA Infection in a New NICU During the COVID-19 Pandemic. Pediatrics 2023, 151 PMID: 36625072, DOI: 10.1542/peds.2022-057033.Peer-Reviewed Original ResearchConceptsInvasive MRSA infectionsInfection prevention strategiesMethicillin-resistant Staphylococcus aureusMRSA infectionOutcome measuresPrevention strategiesCOVID-19 pandemicMultidisciplinary quality improvement initiativeLevel IV NICUSubsequent invasive infectionsMRSA colonization rateCoronavirus disease 2019 (COVID-19) pandemicHealthcare Improvement's ModelQuality improvement initiativesDisease 2019 pandemicEffectiveness of interventionsPersonal protective equipmentSupply chain shortagesHospitalized neonatesInvasive infectionsPatient daysSkin colonizationHand hygieneMost NICUsNICU
2022
Sequential organ failure assessment scores to predict outcomes: from adults to neonates
Fleiss N, Polin R. Sequential organ failure assessment scores to predict outcomes: from adults to neonates. Current Opinion In Pediatrics 2022, 35: 218-222. PMID: 36449658, DOI: 10.1097/mop.0000000000001207.Peer-Reviewed Original ResearchConceptsSepsis-attributable mortalityNeonatal sepsisSOFA scoreAttributable mortalityPediatric populationSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreLow birth weight infantsNeonatal disease statesBirth weight infantsRisk of mortalityPatient safety outcomesSepsis definitionsWeight infantsPreterm infantsOrgan dysfunctionPrognostic utilityRisk stratificationClinical progressionAdverse outcomesPatient cohortLaboratory criteriaSeverity scoreSafety outcomesSepsisWhat’s new in the management of neonatal early-onset sepsis?
Fleiss N, Schwabenbauer K, Randis TM, Polin RA. What’s new in the management of neonatal early-onset sepsis? Archives Of Disease In Childhood - Fetal And Neonatal Edition 2022, 108: 10-14. PMID: 35618407, DOI: 10.1136/archdischild-2021-323532.Peer-Reviewed Original ResearchInfection prevention for extremely low birth weight infants in the NICU
Fleiss N, Tarun S, Polin RA. Infection prevention for extremely low birth weight infants in the NICU. Seminars In Fetal And Neonatal Medicine 2022, 27: 101345. PMID: 35550785, PMCID: PMC9006400, DOI: 10.1016/j.siny.2022.101345.Peer-Reviewed Original ResearchConceptsInfection preventionLow birth weight infantsEarly antibiotic exposureBirth weight infantsHuman milk feedingPreterm newborn infantsSARS-CoV-2 global pandemicUse of probioticsAntifungal prophylaxisEnteral feedingWeight infantsPreterm infantsProlonged hospitalizationEvidence-based practiceMilk feedingNewborn infantsAntibiotic exposureInvasive interventionsSystemic infectionImmune defenseInfantsInfectionPreventionSuch interventionsNICU
2021
Can we back off using antibiotics in the NICU?
Fleiss N, Hooven TA, Polin RA. Can we back off using antibiotics in the NICU? Seminars In Fetal And Neonatal Medicine 2021, 26: 101217. PMID: 33678550, DOI: 10.1016/j.siny.2021.101217.Peer-Reviewed Original ResearchConceptsMulti-drug resistant organismsLong-term adverse effectsCulture-positive sepsisAntibiotic prescribing practicesDelaying antibioticsNeonatal sepsisPositive sepsisPrescribing practicesAntibiotic utilizationNeonatal ICUAntibiotic stewardshipAntibiotic useAntibiotic overuseResistant organismsAdverse effectsAntibioticsSepsisNICUInfantsLaboratory testingICUNeonatesSpecified intervalsNeonatologistsEvaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection
Fleiss N, Coggins SA, Lewis AN, Zeigler A, Cooksey KE, Walker LA, Husain AN, de Jong BS, Wallman-Stokes A, Alrifai MW, Visser DH, Good M, Sullivan B, Polin RA, Martin CR, Wynn JL. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection. JAMA Network Open 2021, 4: e2036518. PMID: 33538825, PMCID: PMC7862993, DOI: 10.1001/jamanetworkopen.2020.36518.Peer-Reviewed Original ResearchMeSH KeywordsBacteremiaCatheter-Related InfectionsFemaleFungemiaGestational AgeGram-Negative Bacterial InfectionsGram-Positive Bacterial InfectionsHospital MortalityHumansInfant, Extremely Low Birth WeightInfant, Extremely PrematureInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightIntensive Care Units, NeonatalIntestinal PerforationMaleNeonatal SepsisOrgan Dysfunction ScoresPeritonitisPrognosisRisk AssessmentConceptsSequential Organ Failure AssessmentInfection-related mortalityLate-onset infectionOrgan Failure AssessmentPreterm infantsMortality riskConsensus definitionAcademic neonatal intensive care unitMulticenter retrospective cohort studyNeonatal intensive care unitMedian birth weightRetrospective cohort studyMedian gestational ageIntensive care unitCharacteristic curveFailure AssessmentTime of evaluationWeight infantsCohort studyOnset infectionPrimary outcomeTotal cohortCare unitGestational ageBirth weightSubdural extravasation of crystalloids and blood products through a scalp peripheral intravenous catheter into the subdural space of a neonate on veno-arterial extracorporeal membrane oxygenation.
Fleiss N, Klein-Cloud R, Gill B, Feldstein NA, Fallon EM, Ruzal-Shapiro C, Collins A. Subdural extravasation of crystalloids and blood products through a scalp peripheral intravenous catheter into the subdural space of a neonate on veno-arterial extracorporeal membrane oxygenation. Journal Of Neonatal-perinatal Medicine 2021 PMID: 33523026, DOI: 10.3233/NPM-200610.Peer-Reviewed Original Research