2018
Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes
Liu M, Peng J, Tai N, Pearson JA, Hu C, Guo J, Hou L, Zhao H, Wong FS, Wen L. Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes. Diabetologia 2018, 61: 2333-2343. PMID: 30094467, PMCID: PMC6182661, DOI: 10.1007/s00125-018-4705-0.Peer-Reviewed Original ResearchConceptsToll-like receptorsType 1 diabetesRole of TLR9Beta-cell functionNOD miceBeta-cell developmentBeta cellsGlucose toleranceTLR9 antagonistFirst-phase insulin secretory responseInnate immune Toll-like receptorsRole of TLRsImmune Toll-like receptorsWild-type NOD miceType 1 diabetes developmentToll-like receptor 9Absence of TLR9Cell functionIslet beta-cell growthBeta cell numberInsulin secretory responseEnhanced glucose toleranceIslet beta cellsPotential therapeutic targetBeta-cell growth
2013
TLR9 Deficiency Promotes CD73 Expression in T Cells and Diabetes Protection in Nonobese Diabetic Mice
Tai N, Wong FS, Wen L. TLR9 Deficiency Promotes CD73 Expression in T Cells and Diabetes Protection in Nonobese Diabetic Mice. The Journal Of Immunology 2013, 191: 2926-2937. PMID: 23956420, PMCID: PMC3788667, DOI: 10.4049/jimmunol.1300547.Peer-Reviewed Original ResearchConceptsNOD miceCD73 expressionT cellsTLR9 deficiencyDiabetes developmentImmune cellsAnti-inflammatory cytokine productionImproved β-cell functionImportant immune regulatory roleStrong immunosuppressive functionNonobese diabetic (NOD) miceIncidence of diabetesNOD mouse modelPeripheral lymphoid tissuesImmune regulatory roleType 1 diabetesΒ-cell functionNew therapeutic strategiesElevated frequencyNOD backgroundDiabetes protectionDiabetic miceImmunosuppressive functionProinflammatory cytokinesCytokine production