2018
Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes
Liu M, Peng J, Tai N, Pearson JA, Hu C, Guo J, Hou L, Zhao H, Wong FS, Wen L. Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes. Diabetologia 2018, 61: 2333-2343. PMID: 30094467, PMCID: PMC6182661, DOI: 10.1007/s00125-018-4705-0.Peer-Reviewed Original ResearchConceptsToll-like receptorsType 1 diabetesRole of TLR9Beta-cell functionNOD miceBeta-cell developmentBeta cellsGlucose toleranceTLR9 antagonistFirst-phase insulin secretory responseInnate immune Toll-like receptorsRole of TLRsImmune Toll-like receptorsWild-type NOD miceType 1 diabetes developmentToll-like receptor 9Absence of TLR9Cell functionIslet beta-cell growthBeta cell numberInsulin secretory responseEnhanced glucose toleranceIslet beta cellsPotential therapeutic targetBeta-cell growthTRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells
Gülden E, Chao C, Tai N, Pearson JA, Peng J, Majewska-Szczepanik M, Zhou Z, Wong FS, Wen L. TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells. Journal Of Autoimmunity 2018, 93: 57-65. PMID: 29960834, PMCID: PMC6108920, DOI: 10.1016/j.jaut.2018.06.003.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Vesicular TransportAdoptive TransferAnimalsBacteroidetesBurkholderialesCell ProliferationDendritic CellsDiabetes Mellitus, ExperimentalDisease SusceptibilityFemaleFirmicutesGastrointestinal MicrobiomeGene Expression RegulationLymphocyte ActivationMiceMice, Inbred NODMice, KnockoutMyeloid Differentiation Factor 88Signal TransductionT-LymphocytesToll-Like Receptor 3Toll-Like Receptor 4ConceptsWT NOD miceNOD miceType 1 diabetesGut microbiotaDiabetes developmentDendritic cellsCell activationNon-obese diabetic (NOD) mouse modelMyeloid differentiation primary response gene 88Wild-type NOD miceNon-obese diabetic (NOD) miceToll-like receptor signalingDiabetes susceptibilityStrong inflammatory immune responseDevelopment of diabetesInflammatory immune responseDiabetic mouse modelAdapter-inducing interferonImmune cell activationT cell activationTRIF deficiencyAdaptor protein downstreamFurther immunological analysisHuman T1D.T1D development
2016
The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes
Tai N, Wong FS, Wen L. The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes. Journal Of Autoimmunity 2016, 71: 26-34. PMID: 27021275, PMCID: PMC4903935, DOI: 10.1016/j.jaut.2016.03.006.Peer-Reviewed Original ResearchConceptsPattern recognition receptorsToll-like receptorsInnate immunityCell autoimmunityAdaptive immunityHuman studiesOrgan-specific autoimmune diseasesT cell-mediated destructionΒ-cellsInsulin-producing pancreatic β-cellsDifferent pattern recognition receptorsCell-mediated destructionDevelopment of T1D.Pathogenesis of T1D.Type 1 diabetesFunctional β-cell massNovel therapeutic strategiesInnate immune responseInnate immune systemΒ-cell massPancreatic beta cellsShape adaptive immunityPancreatic β-cellsIslet β-cellsNOD mice