2018
Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice
Tan Q, Tai N, Li Y, Pearson J, Pennetti S, Zhou Z, Wong FS, Wen L. Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice. JCI Insight 2018, 3: e95882. PMID: 29321370, PMCID: PMC5821212, DOI: 10.1172/jci.insight.95882.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsAutoantibodiesAutoimmunityB-LymphocytesCytidine DeaminaseCytokinesDiabetes Mellitus, Type 1Enzyme ActivationFemaleGene Knockdown TechniquesImmune ToleranceImmunoglobulin AImmunoglobulin GInsulinInterferon-gammaLymph NodesMaleMiceMice, Inbred NODMilkPlacentaPregnancySpleenT-LymphocytesVirulenceConceptsDiabetes developmentB cellsT cellsNOD miceActivation-induced cytidine deaminaseType 1 diabetes developmentAccelerated diabetes developmentAnti-insulin autoantibodiesIFN-γ expressionMore rapid onsetB cell interactionsRole of AIDAccelerated T1DActivation-induced cytidine deaminase (AID) deficiencyAutoimmune diabetesIslet autoimmunityT1D developmentImmune toleranceMaternal IgGT-betRapid onsetPresence of AIDMiceDeaminase deficiencyCD4
2016
The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model
Yuksel M, Xiao X, Tai N, Vijay M, Gülden E, Beland K, Lapierre P, Alvarez F, Hu Z, Colle I, Ma Y, Wen L. The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model. Clinical & Experimental Immunology 2016, 186: 164-176. PMID: 27414259, PMCID: PMC5054566, DOI: 10.1111/cei.12843.Peer-Reviewed Original ResearchMeSH KeywordsAmmonia-LyasesAnimalsAntigen-Presenting CellsAutoantibodiesAutoantigensCD8-Positive T-LymphocytesCytochrome P-450 CYP2D6CytokinesDisease Models, AnimalGlutamate FormimidoyltransferaseHepatitis, AutoimmuneHLA-DR4 AntigenHumansHypergammaglobulinemiaImmunizationImmunoglobulin GInflammation MediatorsMiceMice, Inbred NODMice, TransgenicMultienzyme ComplexesMultifunctional EnzymesPlasma CellsT-Lymphocyte SubsetsConceptsDevelopment of AIHAutoimmune hepatitisHLA-DR4DR4 miceT cellsAnti-liver kidney microsomal type 1Anti-liver cytosol type 1Induction of AIHWild-type NOD miceNon-obese diabetic (NOD) miceType 1Key immune cell subsetsAnti-smooth muscle actinAdult autoimmune hepatitisHepatitis mouse modelElevated alanine aminotransferasePD-1 expressionPlasma cell infiltrationChronic liver diseaseRegulatory T cellsMild liver injuryImmune cell subsetsPersistent liver damageAntigen-presenting cellsHuman leucocyte antigen
2015
A novel “humanized mouse” model for autoimmune hepatitis and the association of gut microbiota with liver inflammation
Yuksel M, Wang Y, Tai N, Peng J, Guo J, Beland K, Lapierre P, David C, Alvarez F, Colle I, Yan H, Mieli-Vergani G, Vergani D, Ma Y, Wen L. A novel “humanized mouse” model for autoimmune hepatitis and the association of gut microbiota with liver inflammation. Hepatology 2015, 62: 1536-1550. PMID: 26185095, PMCID: PMC4763614, DOI: 10.1002/hep.27998.Peer-Reviewed Original ResearchConceptsAnti-liver cytosol type 1 autoantibodiesAnti-liver kidney microsomal type 1Autoimmune hepatitisHLA-DR3Type 1Antigenic targetsAntinuclear autoantibodiesAnti-liver cytosol type 1T helper 1 immune responseHelper 1 immune responsePathogenesis of AIHSevere inflammatory liver diseaseTypes of AIHHLA-DR3 transgenic miceAnti-smooth muscleInflammatory liver diseaseAssociation of HLANonobese diabetic (NOD) miceRegulatory T cellsImmune cell infiltrationNovel mouse modelNonobese diabetic (NOD) backgroundHumanized animal modelsFormiminotransferase cyclodeaminaseAIH-1
2009
Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice
Xiao X, Ma B, Dong B, Zhao P, Tai N, Chen L, Wong FS, Wen L. Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice. Journal Of Autoimmunity 2009, 32: 85-93. PMID: 19200691, DOI: 10.1016/j.jaut.2008.12.003.Peer-Reviewed Original ResearchConceptsDiabetic NOD miceNOD miceDiabetic nephropathyDiabetic miceNon-diabetic NOD miceNon-obese diabetic (NOD) miceDuration of diabetesUrinary albumin excretionAdditional therapeutic targetsHumoral immune responseAlbumin excretionAutoimmune diabetesDendritic cellsDiabetes onsetImmune changesKidney weightIgG depositsHumoral immunityT cellsImmune responseNephropathyComplement C3Therapeutic targetB cellsImmune system