2015
Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs
Hu Y, Peng J, Tai N, Hu C, Zhang X, Wong FS, Wen L. Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs. The Journal Of Immunology 2015, 195: 4176-4184. PMID: 26401004, PMCID: PMC4765177, DOI: 10.4049/jimmunol.1500884.Peer-Reviewed Original ResearchConceptsNOD miceTolerogenic APCsDiabetes developmentT cell-mediated autoimmune diseaseDiabetogenic CD8 T cellsCell-mediated autoimmune diseasePolymyxin BCD8 T cellsNonobese diabetic (NOD) miceType 1 diabetesHost immune systemIslet β-cellsAutoimmune diabetesDifferent time pointsImmune toleranceDiabetic miceAutoimmune diseasesProfound protectionT cellsImmune responseProtective effectCommensal microbiotaGut microbiotaSusceptible individualsCommensal bacteria
2012
B cell depletion - a double-edged sword (123.18)
Tai N, Wen L. B cell depletion - a double-edged sword (123.18). The Journal Of Immunology 2012, 188: 123.18-123.18. DOI: 10.4049/jimmunol.188.supp.123.18.Peer-Reviewed Original ResearchB-cell depletionCell depletionT cellsB cellsDay 3B cell depletion therapyAdoptive transfer approachEffector T cellsNOD mouse modelT cell effectorsT cell subsetsSingle-dose injectionSecondary lymphoid organsSplenic T cellsWeek old miceMultiple T cellsRAG miceDepletion therapySplenic CD4ICOS expressionCD4-CD8Control miceAutoimmune diseasesCell subsetsLymphoid organs