2016
Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice
Tai N, Peng J, Liu F, Gulden E, Hu Y, Zhang X, Chen L, Wong FS, Wen L. Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice. Journal Of Experimental Medicine 2016, 213: 2129-2146. PMID: 27621416, PMCID: PMC5030808, DOI: 10.1084/jem.20160526.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, BacterialCD8-Positive T-LymphocytesCell DifferentiationDiabetes Mellitus, ExperimentalFemaleGastrointestinal MicrobiomeGlucose-6-PhosphataseLymphocyte ActivationMice, Inbred C57BLMice, Inbred NODMyeloid Differentiation Factor 88PeptidesReceptors, Antigen, T-CellT-Lymphocytes, RegulatoryThymus GlandConceptsCD8 T cellsT cellsCommensal bacteriaSignificant homologyDiabetes developmentGut microbiotaDiabetogenic CD8 T cellsPathogenic CD8 T cellsTransgenic nonobese diabetic miceGut microbesType 1 diabetes developmentIslet-specific glucose-6-phosphatase catalytic subunit-related proteinNovel mechanismNonobese diabetic (NOD) miceInnate immunityBacteriaMolecular mimicryNOD miceIslet autoantigensT1D developmentDiabetic miceMicrobial antigensCellsAnimal modelsHuman studies
2011
IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice
Tai N, Yasuda H, Xiang Y, Zhang L, Rodriguez-Pinto D, Yokono K, Sherwin R, Wong FS, Nagata M, Wen L. IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice. Clinical Immunology 2011, 139: 336-349. PMID: 21458378, DOI: 10.1016/j.clim.2011.03.003.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsB7-1 AntigenDendritic CellsDiabetes Mellitus, Type 1Disease Models, AnimalFemaleHLA-DQ AntigensHumansImmune ToleranceImmunophenotypingInsulin-Secreting CellsInterleukin-10Lymphocyte ActivationMaleMiceMice, Inbred BALB CMice, Inbred NODMice, SCIDMice, TransgenicSpecific Pathogen-Free OrganismsT-LymphocytesConceptsRIP-B7.1 miceAutoimmune diabetesIL-10IL-10-treated DCIL-12/23 p40T cell toleranceT cell proliferationDifferent animal modelsNew therapeutic interventionsSpontaneous diabetesRegulatory cellsDendritic cellsImmune toleranceCostimulatory moleculesIL-6IL-4T cellsAnimal modelsCell toleranceTherapeutic interventionsDiabetesCell proliferationT1D.MiceCells