2020
Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals
Xu K, Li B, McGinnis KA, Vickers-Smith R, Dao C, Sun N, Kember RL, Zhou H, Becker WC, Gelernter J, Kranzler HR, Zhao H, Justice AC. Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals. Nature Communications 2020, 11: 5302. PMID: 33082346, PMCID: PMC7598939, DOI: 10.1038/s41467-020-18489-3.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesLarge genome-wide association studiesMillion Veteran ProgramAssociation studiesExpression quantitative trait lociQuantitative trait lociChromatin interactionsComplex traitsFunctional annotationTrait lociSequencing ConsortiumDozen genesSignificant lociSmoking phenotypesLociMultiple populationsNew insightsPhenotypeVeteran ProgramGenetic vulnerabilityGenesTraitsAnnotationEuropean AmericansConsortiumStatistical Methods in Genome-Wide Association Studies
Sun N, Zhao H. Statistical Methods in Genome-Wide Association Studies. Annual Review Of Biomedical Data Science 2020, 3: 1-24. DOI: 10.1146/annurev-biodatasci-030320-041026.Peer-Reviewed Original ResearchGenome-wide association studiesAssociation studiesTraits of interestGenetic architectureIdentification of variantsGWAS dataStatistical methodologyStatistical challengesGenetic risk prediction modelsGenetic markersStatistical methodsHuman diseasesPhenotype informationGenetic variantsTraitsGenotype informationScientific goalsRecent progressGenesVariantsTens of thousandsHundreds of thousandsPrediction modelPathwayThousands
2016
Arabidopsis SAURs are critical for differential light regulation of the development of various organs
Sun N, Wang J, Gao Z, Dong J, He H, Terzaghi W, Wei N, Deng XW, Chen H. Arabidopsis SAURs are critical for differential light regulation of the development of various organs. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 6071-6076. PMID: 27118848, PMCID: PMC4889401, DOI: 10.1073/pnas.1604782113.Peer-Reviewed Original ResearchConceptsPhytochrome-interacting factorsAuxin levelsType 2C protein phosphatasesElongation of hypocotylsExpansion of cotyledonsSmall auxinArabidopsis seedlingsProtein phosphataseRNA genesHypocotyl elongationCotyledon expansionTranscriptomic analysisLight regulationDifferential regulationCell enlargementHypocotylsSAURPhosphatase activityCotyledonsDifferential growthGenesMutation analysisExpressionRegulationDeetiolation