2020
A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow
Usselman CW, Adler TE, Coovadia Y, Leone C, Paidas MJ, Stachenfeld NS. A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow. AJP Heart And Circulatory Physiology 2020, 318: h581-h589. PMID: 32004082, DOI: 10.1152/ajpheart.00578.2019.Peer-Reviewed Original ResearchConceptsMuscle sympathetic nerve activitySympathetic nerve activityArterial stiffnessBaroreflex sensitivityPreeclamptic womenUncomplicated pregnanciesNerve activityBlood pressureCardiovascular diseaseCentral pulse wave velocityCardiovagal baroreflex sensitivityElevated arterial stiffnessMuscle sympathetic outflowElevated cardiovascular riskHistory of preeclampsiaNormal blood pressurePeripheral arterial stiffnessSympathetic baroreflex sensitivitySympathetic nervous systemPulse wave velocityHigher MSNACardiovascular dysregulationSympathetic outflowCardiovascular riskNormal pregnancy
2019
Compromised endothelial function in transgender men taking testosterone
Gulanski BI, Flannery CA, Peter PR, Leone CA, Stachenfeld NS. Compromised endothelial function in transgender men taking testosterone. Clinical Endocrinology 2019, 92: 138-144. PMID: 31765022, PMCID: PMC6957681, DOI: 10.1111/cen.14132.Peer-Reviewed Original ResearchConceptsEndothelial functionTransgender menEndothelial dysfunctionCisgender femalesClinical cardiovascular riskCardiovascular risk factorsImpaired endothelial functionEarly follicular phaseAndrogen excessCardiovascular riskVasodilatory responseCoronary arteryHormonal milieuFollicular phaseTestosterone treatmentMenstrual cycleRisk factorsFemale genderAtherosclerotic plaquesEarly signsTestosteroneTotal TSImportant markerDysfunctionMen
2011
Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance
Wenner MM, Taylor HS, Stachenfeld NS. Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance. The Journal Of Physiology 2011, 589: 975-986. PMID: 21173076, PMCID: PMC3060374, DOI: 10.1113/jphysiol.2010.194563.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceHigh orthostatic toleranceOrthostatic toleranceAdrenergic responseAdrenergic responsivenessNitric oxide synthase inhibitor NG-monomethylEndogenous sex hormone productionSynthase inhibitor NG-monomethylSkin blood flow responseBlood flow responseInhibitor NG-monomethylSex hormone productionFemale sex hormonesLower body negative pressure testSkin blood flowGnRH antagonistProgesterone administrationOrthostatic intoleranceNG-monomethylPeripheral αMicrodialysis infusionSex hormonesCyclooxygenase pathwayHT womenAdrenergic control
2010
Tissue Doppler of Early Mitral Filling Correlates With Simulated Volume Loss in Healthy Subjects
Moore CL, Tham ET, Samuels KJ, McNamara RL, Galante NJ, Stachenfeld N, Shelley K, Dziura J, Silverman DG. Tissue Doppler of Early Mitral Filling Correlates With Simulated Volume Loss in Healthy Subjects. Academic Emergency Medicine 2010, 17: 1162-1168. PMID: 21175513, DOI: 10.1111/j.1553-2712.2010.00906.x.Peer-Reviewed Original ResearchConceptsInferior vena cavaLBNP levelsTissue DopplerHealthy subjectsVital signsPulsed-wave tissue DopplerLower body negative pressureLateral mitral annulusEmergency department patientsTissue Doppler assessmentTissue Doppler velocitiesEarly diastolic fillingAccurate noninvasive assessmentPulsed-wave spectral DopplerLate transmitralNegative pressure levelBlood pressureDepartment patientsDoppler assessmentVena cavaDiastolic fillingVolume lossCardiovascular diseaseMitral annulusFilling wave
2001
Selected Contribution: Sex differences in osmotic regulation of AVP and renal sodium handling
Stachenfeld N, Splenser A, Calzone W, Taylor M, Keefe D. Selected Contribution: Sex differences in osmotic regulation of AVP and renal sodium handling. Journal Of Applied Physiology 2001, 91: 1893-1901. PMID: 11568177, DOI: 10.1152/jappl.2001.91.4.1893.Peer-Reviewed Original ResearchConceptsSystolic blood pressureBlood pressureMenstrual phaseBasal plasma AVP concentrationGreater systolic blood pressurePressure-natriuresis curveRenal sodium handlingPlasma osmolalityPlasma AVP concentrationMin of restMidluteal menstrual phasesBasal plasma osmolalitySex differencesSodium handlingPulse pressureBody wtAVP concentrationAVP releaseNaCl infusionHormone responseMenWomenGreater sensitivityBody waterOsmolality