2022
Consequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II
Shawky NM, Dalmasso C, Ojeda NB, Zuchowski Y, Stachenfeld N, Alexander BT, Reckelhoff JF. Consequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II. Journal Of Hypertension 2022, 40: 712-722. PMID: 34980865, PMCID: PMC8897268, DOI: 10.1097/hjh.0000000000003067.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeAttenuated pressor responsesPressor responseBlood pressureAng IIHyperandrogenemic femalesAngiotensin IIFemale offspringModel of PCOSNitrate/nitrite excretionSimilar baseline blood pressureIntrarenal Ang IIBaseline blood pressureElevated blood pressureExaggerated pressor responseHigh-salt dietLow birth weightFemale control offspringDihydrotestosterone pelletsMaternal hyperandrogenemiaMore proteinuriaPCOS womenOvary syndromeRenal injurySalt diet
2020
A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow
Usselman CW, Adler TE, Coovadia Y, Leone C, Paidas MJ, Stachenfeld NS. A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow. AJP Heart And Circulatory Physiology 2020, 318: h581-h589. PMID: 32004082, DOI: 10.1152/ajpheart.00578.2019.Peer-Reviewed Original ResearchConceptsMuscle sympathetic nerve activitySympathetic nerve activityArterial stiffnessBaroreflex sensitivityPreeclamptic womenUncomplicated pregnanciesNerve activityBlood pressureCardiovascular diseaseCentral pulse wave velocityCardiovagal baroreflex sensitivityElevated arterial stiffnessMuscle sympathetic outflowElevated cardiovascular riskHistory of preeclampsiaNormal blood pressurePeripheral arterial stiffnessSympathetic baroreflex sensitivitySympathetic nervous systemPulse wave velocityHigher MSNACardiovascular dysregulationSympathetic outflowCardiovascular riskNormal pregnancy
2017
Contribution of Increased Angiotensin II Sensitivity to Microvascular Dysfunction in Women With a History of Preeclampsia
Usselman CW, Stachenfeld NS. Contribution of Increased Angiotensin II Sensitivity to Microvascular Dysfunction in Women With a History of Preeclampsia. Hypertension 2017, 70: 245-246. PMID: 28652470, DOI: 10.1161/hypertensionaha.117.09527.Peer-Reviewed Original Research
2012
Blood pressure and water regulation: understanding sex hormone effects within and between men and women
Wenner MM, Stachenfeld NS. Blood pressure and water regulation: understanding sex hormone effects within and between men and women. The Journal Of Physiology 2012, 590: 5949-5961. PMID: 23027816, PMCID: PMC3530109, DOI: 10.1113/jphysiol.2012.236752.Peer-Reviewed Original ResearchConceptsOvarian hormone exposureBlood pressureHormone exposureHormone effectsYoung womenOvarian hormone effectsSuppress reproductive functionBlood pressure controlFirst-line treatmentSex differencesEffects of estrogenPlasma volume expansionCause of deathSex hormone effectsBody fluid regulationGreater morbidityHealthy womenLine treatmentOvarian hormonesMenopausal womenBody water balanceOrthostatic toleranceProgesterone exposureMenstrual cycleHormone administration