2023
The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine
Hunter S, Angadi S, Bhargava A, Harper J, Hirschberg A, Levine B, Moreau K, Nokoff N, Stachenfeld N, Bermon S. The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine. Translational Journal Of The American College Of Sports Medicine 2023, 8: 1-33. DOI: 10.1249/tjx.0000000000000236.Peer-Reviewed Original ResearchSex steroid hormonesConsensus statementAthletic performanceEndogenous sex steroid hormonesSex differencesSteroid hormonesOnset of pubertyExercise trainingMuscle strengthAcute boutFundamental sex differencesSex hormonesAmerican CollegeParticular testosteroneAdult menSports medicineTraining statusHigh-impact studiesHormoneSimilar ageNonphysiological factorsPrimary determinantMalesBiological basisWomenThe Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine
HUNTER S, ANGADI S, BHARGAVA A, HARPER J, HIRSCHBERG A, LEVINE B, MOREAU K, NOKOFF N, STACHENFELD N, BERMON S. The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine. Medicine & Science In Sports & Exercise 2023, 55: 2328-2360. PMID: 37772882, DOI: 10.1249/mss.0000000000003300.Peer-Reviewed Original ResearchConceptsSex steroid hormonesConsensus statementAthletic performanceEndogenous sex steroid hormonesSex differencesSteroid hormonesOnset of pubertyExercise trainingMuscle strengthAcute boutFundamental sex differencesSex hormonesAmerican CollegeParticular testosteroneAdult menSports medicineTraining statusHigh-impact studiesHormoneSimilar ageNonphysiological factorsPrimary determinantMalesBiological basisWomen
2022
Are there sex differences in risk for exertional heat stroke? A translational approach
Giersch GEW, Garcia CK, Stachenfeld N, Charkoudian N. Are there sex differences in risk for exertional heat stroke? A translational approach. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2022, 107: 1136-1143. PMID: 35598159, DOI: 10.1113/ep090402.Peer-Reviewed Original ResearchConceptsExertional heat strokeHeat strokeRisk factorsTranslational approachCentral nervous system dysfunctionNervous system dysfunctionFemale sex hormonesSex differencesHuman researchOrgan damageFatal conditionSystem dysfunctionSex hormonesPhysical activityStrokeTranslational modelOccupational workersRiskMilitary personnelAnimalsTreatmentHuman modelReviewFuture investigationsPhysiological differences
2020
Pathophysiological effects of androgens on the female vascular system
Stone T, Stachenfeld NS. Pathophysiological effects of androgens on the female vascular system. Biology Of Sex Differences 2020, 11: 45. PMID: 32727622, PMCID: PMC7391603, DOI: 10.1186/s13293-020-00323-6.ChaptersConceptsFemale cardiovascular systemPolycystic ovary syndromeFemale vasculatureHormone therapyOvary syndromePathophysiological effectsCardiovascular systemTransgender menPrimary medical interventionSignificant medical risksHigh blood pressureCardiovascular disease statesEffects of testosteroneEndogenous androgen concentrationsSex differencesPotential causative linkChronic hyperandrogenismTestosterone dosesEndothelial dysfunctionBlood pressurePatient groupVascular functionCardiovascular regulationSex hormonesAndrogen receptor
2018
Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan
Stanhewicz AE, Wenner MM, Stachenfeld NS. Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan. AJP Heart And Circulatory Physiology 2018, 315: h1569-h1588. PMID: 30216121, PMCID: PMC6734083, DOI: 10.1152/ajpheart.00396.2018.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEndothelial functionHealthy young womenCardiovascular diseaseVascular healthSex hormonesCardiovascular systemOverall cardiovascular disease riskSex differencesYoung womenAge-associated endothelial dysfunctionRenin-angiotensin systemPredictor of atherosclerosisAtherosclerotic cardiovascular diseaseCardiovascular disease riskCause of morbidityMale sex hormonesReceptor-independent mechanismVascular endothelinCVD riskEndothelial dysfunctionAge-related declineEarly decrementsFemale hormonesSimilar age-related declineCVD increases
2012
Blood pressure and water regulation: understanding sex hormone effects within and between men and women
Wenner MM, Stachenfeld NS. Blood pressure and water regulation: understanding sex hormone effects within and between men and women. The Journal Of Physiology 2012, 590: 5949-5961. PMID: 23027816, PMCID: PMC3530109, DOI: 10.1113/jphysiol.2012.236752.Peer-Reviewed Original ResearchConceptsOvarian hormone exposureBlood pressureHormone exposureHormone effectsYoung womenOvarian hormone effectsSuppress reproductive functionBlood pressure controlFirst-line treatmentSex differencesEffects of estrogenPlasma volume expansionCause of deathSex hormone effectsBody fluid regulationGreater morbidityHealthy womenLine treatmentOvarian hormonesMenopausal womenBody water balanceOrthostatic toleranceProgesterone exposureMenstrual cycleHormone administration
2001
Selected Contribution: Sex differences in osmotic regulation of AVP and renal sodium handling
Stachenfeld N, Splenser A, Calzone W, Taylor M, Keefe D. Selected Contribution: Sex differences in osmotic regulation of AVP and renal sodium handling. Journal Of Applied Physiology 2001, 91: 1893-1901. PMID: 11568177, DOI: 10.1152/jappl.2001.91.4.1893.Peer-Reviewed Original ResearchConceptsSystolic blood pressureBlood pressureMenstrual phaseBasal plasma AVP concentrationGreater systolic blood pressurePressure-natriuresis curveRenal sodium handlingPlasma osmolalityPlasma AVP concentrationMin of restMidluteal menstrual phasesBasal plasma osmolalitySex differencesSodium handlingPulse pressureBody wtAVP concentrationAVP releaseNaCl infusionHormone responseMenWomenGreater sensitivityBody waterOsmolality