2019
Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor
Usselman CW, Yarovinsky T, Steele FE, Leone CA, Taylor HS, Bender JR, Stachenfeld NS. Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor. The Journal Of Physiology 2019, 597: 2853-2865. PMID: 30847930, DOI: 10.1113/jp277756.Peer-Reviewed Original ResearchMeSH KeywordsAdultAndrogensCardiovascular DiseasesDihydrotestosteroneEndothelin-1Endothelium, VascularEstrogensEthinyl EstradiolFemaleGlucose Tolerance TestHumansMicrovesselsNitric OxideObesityPolycystic Ovary SyndromeReceptor, Endothelin BSkinVascular Endothelial Growth Factor AVasodilationYoung AdultConceptsPolycystic ovary syndromeCardiovascular dysfunctionEndothelial dysfunctionOvary syndromeEndothelin-1Endothelial functionNO productionAndrogen receptor-dependent mannerEndothelin-B receptor subtypeCardiovascular risk factorsMicrovascular endothelial dysfunctionMicrovascular endothelial functionCutaneous vascular conductanceB receptor subtypesEndothelin B receptorLaser Doppler flowmetryNitric oxide inhibitionReceptor-dependent mannerEndothelial cell NO productionDose-response curveVasodilating responsePCOS subjectsLean womenObese womenVascular conductance
2017
Microvascular endothelial function in lean versus obese women with polycystic ovary syndrome: role of the endothelin B receptor
Usselman C, Taylor H, Stachenfeld N. Microvascular endothelial function in lean versus obese women with polycystic ovary syndrome: role of the endothelin B receptor. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.691.5.Peer-Reviewed Original ResearchPolycystic ovary syndromeLean polycystic ovary syndromeObese PCOS womenCutaneous vascular conductanceNitric oxide inhibitionObese womenET-1PCOS womenOvary syndromeVasodilatory responseEndothelial functionOxide inhibitionEndothelin receptor subtype BObese polycystic ovary syndromeIntradermal microdialysis perfusionCardiovascular risk factorsMicrovascular endothelial functionPlasma endothelin-1Adverse cardiovascular outcomesAmerican Heart AssociationEndothelin B receptorLaser Doppler flowmetryDose-response curveCardiovascular outcomesIndependent vasodilation