2024
Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia
Berbrier D, Adler T, Leone C, Paidas M, Stachenfeld N, Usselman C. Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia. AJP Heart And Circulatory Physiology 2024, 327: h140-h154. PMID: 38700469, DOI: 10.1152/ajpheart.00020.2024.Peer-Reviewed Original ResearchMuscle sympathetic nerve activitySystolic blood pressureResponse to acute stimuliIsometric handgrip exercise protocolMental stressHandgrip exercise protocolCardiovascular diseaseExercise-induced increaseEffective prevention strategiesAcute stimuliExercise protocolHistory of preeclampsiaBlood pressureIntegrated muscle sympathetic nerve activityElevated long-term riskElevated cardiovascular riskLong-term riskEnd-expiratory apneaSympathetic nerve activityPrevention strategiesHandgrip exerciseBlood pressure responseRisk factorsExaggerated pressorHealthy pregnancy
2022
Sympathetic Responses to Isometric Handgrip Exercise in Women following Preeclamptic Pregnancies
Orr H, Adler T, Leone C, Paidas M, Stachenfeld N, Usselman C. Sympathetic Responses to Isometric Handgrip Exercise in Women following Preeclamptic Pregnancies. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r4218.Peer-Reviewed Original ResearchMuscle sympathetic nerve activityPost-exercise circulatory occlusionHand-grip exerciseElevated muscle sympathetic nerve activityHP womenMSNA responsesPreeclamptic pregnanciesBaseline muscle sympathetic nerve activityIsometric hand-grip exerciseSympathetic nerve activityIsometric handgrip exerciseTotal peripheral resistanceHG exerciseSympathetic dysregulationCardiovascular outcomesCirculatory occlusionHandgrip exerciseArterial pressureHealthy pregnancyNerve activityPE pregnanciesPeripheral resistanceGrip exercisePE womenCardiovascular disease
2021
Androgen Effects on Baroreflex Sensitivity in Women with AE‐PCOS
Stone T, Chiles M, Leone C, Pal L, Stachenfeld N. Androgen Effects on Baroreflex Sensitivity in Women with AE‐PCOS. The FASEB Journal 2021, 35 DOI: 10.1096/fasebj.2021.35.s1.04149.Peer-Reviewed Original ResearchMuscle sympathetic nerve activityLower body negative pressureSympathetic baroreflex sensitivityPolycystic ovary syndromeBaroreflex sensitivityBR controlDiastolic BPHormone suppressionImpaired blood pressure regulationGonadotropin-releasing hormone antagonistOral glucose tolerance testDays of GnRHSympathetic nerve activityInsulin-resistant womenMean arterial pressureVascular resistance changesReproductive-age womenGlucose tolerance testBody negative pressureBlood pressure regulationSuppression of E2Bursts/100 heartbeatsCardiovascular comorbiditiesPCOS phenotypeResistant women
2020
A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow
Usselman CW, Adler TE, Coovadia Y, Leone C, Paidas MJ, Stachenfeld NS. A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow. AJP Heart And Circulatory Physiology 2020, 318: h581-h589. PMID: 32004082, DOI: 10.1152/ajpheart.00578.2019.Peer-Reviewed Original ResearchConceptsMuscle sympathetic nerve activitySympathetic nerve activityArterial stiffnessBaroreflex sensitivityPreeclamptic womenUncomplicated pregnanciesNerve activityBlood pressureCardiovascular diseaseCentral pulse wave velocityCardiovagal baroreflex sensitivityElevated arterial stiffnessMuscle sympathetic outflowElevated cardiovascular riskHistory of preeclampsiaNormal blood pressurePeripheral arterial stiffnessSympathetic baroreflex sensitivitySympathetic nervous systemPulse wave velocityHigher MSNACardiovascular dysregulationSympathetic outflowCardiovascular riskNormal pregnancy
2018
Sympathetic Nervous System Reactivity in Women following Preeclamptic Pregnancies
Usselman C, Adler T, Leone C, Paidas M, Stachenfeld N. Sympathetic Nervous System Reactivity in Women following Preeclamptic Pregnancies. The FASEB Journal 2018, 32: 714.7-714.7. DOI: 10.1096/fasebj.2018.32.1_supplement.714.7.Peer-Reviewed Original ResearchMuscle sympathetic nerve activityPreeclamptic pregnanciesWomen 6Cardiovascular diseaseBaseline muscle sympathetic nerve activitySympathetic nervous system dysregulationBaseline mean arterial pressureSympathetic nervous system responsesSympathetic nerve activityHistory of preeclampsiaMean arterial pressureTotal peripheral resistanceSympathetic nervous system reactivityChronic sympathetic activationDepartment of ObstetricsSympathetic nervous systemLife-long riskNervous system dysregulationNervous system responsesGreater sympathetic reactivityFull-text articlesChemoreflex stressMSNA responsesPreeclamptic womenArterial pressure