2013
Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol
Wenner MM, Haddadin A, Taylor HS, Stachenfeld NS. Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol. The Journal Of Physiology 2013, 591: 2345-2355. PMID: 23401618, PMCID: PMC3650699, DOI: 10.1113/jphysiol.2012.247882.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceE2 administrationOrthostatic toleranceVascular resistanceBlood pressureStroke volumeHeart rateGonadotrophin-releasing hormone antagonistLevels of LBNPLower central volumeReproductive hormone productionAdministration of E2Peripheral vascular resistanceBeat blood pressureAutonomic cardiovascular regulationLower stroke volumeLower body negative pressure testHeart rate responseInfluence of oestradiolBaroreflex controlTolerant womenHormone antagonistCardiovascular regulationPeripheral vasoconstrictionAutonomic control
2011
Estrogen enhances baroreflex sensitivity in women with low orthostatic tolerance
Wenner M, Taylor H, Haddadin A, Stachenfeld N. Estrogen enhances baroreflex sensitivity in women with low orthostatic tolerance. The FASEB Journal 2011, 25: 647.3-647.3. DOI: 10.1096/fasebj.25.1_supplement.647.3.Peer-Reviewed Original ResearchCardiovagal baroreflex sensitivityBaroreflex sensitivityLow orthostatic toleranceOrthostatic toleranceCumulative stress indexPlasma E2Endogenous sex hormone productionGnRH antagonist administrationBlood pressure responseSex hormone productionLower body negative pressure testBaseline BPAntagonist administrationBaroreflex functionSystolic BPE2 administrationOrthostatic intoleranceE2 conditionsBolus infusionHT womenNegative pressure testProgesterone concentrationsSodium nitroprussideGnRHaDay 5Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance
Wenner MM, Taylor HS, Stachenfeld NS. Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance. The Journal Of Physiology 2011, 589: 975-986. PMID: 21173076, PMCID: PMC3060374, DOI: 10.1113/jphysiol.2010.194563.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceHigh orthostatic toleranceOrthostatic toleranceAdrenergic responseAdrenergic responsivenessNitric oxide synthase inhibitor NG-monomethylEndogenous sex hormone productionSynthase inhibitor NG-monomethylSkin blood flow responseBlood flow responseInhibitor NG-monomethylSex hormone productionFemale sex hormonesLower body negative pressure testSkin blood flowGnRH antagonistProgesterone administrationOrthostatic intoleranceNG-monomethylPeripheral αMicrodialysis infusionSex hormonesCyclooxygenase pathwayHT womenAdrenergic control