Consequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II
Shawky NM, Dalmasso C, Ojeda NB, Zuchowski Y, Stachenfeld N, Alexander BT, Reckelhoff JF. Consequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II. Journal Of Hypertension 2022, 40: 712-722. PMID: 34980865, PMCID: PMC8897268, DOI: 10.1097/hjh.0000000000003067.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeAttenuated pressor responsesPressor responseBlood pressureAng IIHyperandrogenemic femalesAngiotensin IIFemale offspringModel of PCOSNitrate/nitrite excretionSimilar baseline blood pressureIntrarenal Ang IIBaseline blood pressureElevated blood pressureExaggerated pressor responseHigh-salt dietLow birth weightFemale control offspringDihydrotestosterone pelletsMaternal hyperandrogenemiaMore proteinuriaPCOS womenOvary syndromeRenal injurySalt diet