2024
Deviation From Personalized Blood Pressure Targets Correlates With Worse Outcome After Successful Recanalization
Zhang Z, Pu Y, Yu L, Bai H, Duan W, Liu X, Nie X, Wen Z, Zheng L, Hu X, Leng X, Pan Y, Petersen N, Liu L. Deviation From Personalized Blood Pressure Targets Correlates With Worse Outcome After Successful Recanalization. Journal Of The American Heart Association 2024, 13: e033633. PMID: 38533955, PMCID: PMC11179781, DOI: 10.1161/jaha.123.033633.Peer-Reviewed Original ResearchConceptsBlood pressure targetsBlood pressureAutoregulatory limitsWorse outcomesAssociated with symptomatic intracranial hemorrhageAssociated with unfavorable clinical outcomesPressure targetsAssociated with worse outcomesAssociated with poor outcomesSignificant infarction growthSymptomatic intracranial hemorrhageUnfavorable clinical outcomeLarge vessel occlusion strokeAcute ischemic strokeMean velocity indexIntracranial hemorrhageBP management strategiesNeurological deteriorationClinical outcomesInfarct growthPoor outcomeEndovascular thrombectomyOcclusion strokeRecanalizationIschemic stroke
2023
Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study
Prasad A, Gilmore E, Kim J, Begunova L, Olexa M, Beekman R, Falcone G, Matouk C, Ortega-Gutierrez S, Temkin N, Barber J, Diaz-Arrastia R, de Havenon A, Petersen N. Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study. Neurocritical Care 2023, 1-9. PMID: 38158481, PMCID: PMC11285118, DOI: 10.1007/s12028-023-01896-x.Peer-Reviewed Original ResearchCerebral perfusion pressureBrain tissue hypoxiaSevere traumatic brain injuryTissue hypoxiaTraumatic brain injuryBlood pressureCerebral hypoperfusionBrain injuryAutoregulatory functionMean cerebral perfusion pressureSecondary analysisOptimal cerebral perfusion pressurePercent timeCerebral autoregulatory functionLimits of autoregulationPhase II trialArterial blood pressureBrain tissue oxygenIntracranial pressure monitoringCPP augmentationHemodynamic augmentationAutoregulatory indexII trialBP managementPerfusion pressureAssociation between intraprocedural drops in blood pressure and infarct growth rate patterns after acute large-vessel occlusions
Galecio-Castillo M, Quispe-Orozco D, Farooqui M, Dajles A, Vivanco-Suarez J, Rodriguez-Calienes A, Prasad A, Begunova L, Petersen N, Ortega-Gutierrez S. Association between intraprocedural drops in blood pressure and infarct growth rate patterns after acute large-vessel occlusions. Journal Of NeuroInterventional Surgery 2023, jnis-2023-020899. PMID: 37923382, PMCID: PMC11271969, DOI: 10.1136/jnis-2023-020899.Peer-Reviewed Original ResearchRelative cerebral blood flowInfarct growth ratesFinal infarct volumeHypoperfusion intensity ratioAlberta Stroke Program Early CT ScoreMedian arterial pressureDiffusion-weighted imaging (DWI) magnetic resonance imagingCerebral infarction 2Modified Rankin scoreLarge vessel occlusionEndovascular therapyInfarct volumeStroke onsetBlood pressureAcute large vessel occlusionHealth Stroke Scale scoreStroke Scale scoreAcute ischemic strokeCohort observational studySubgroup of patientsCerebral blood flowBlood pressure dropLVO-AISRankin scoreInfarct growthDynamic cerebral autoregulation in postpartum individuals with and without preeclampsia
Miller E, Katsidoniotaki M, Haghighi N, Dos Santos K, Booker W, Petersen N, Wapner R, Bello N, Kougioumtzoglou I, Marshall R. Dynamic cerebral autoregulation in postpartum individuals with and without preeclampsia. Pregnancy Hypertension 2023, 33: 39-45. PMID: 37524001, PMCID: PMC10528950, DOI: 10.1016/j.preghy.2023.07.176.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationFirst week postpartumPostpartum individualsSevere featuresCerebral autoregulationPostpartum groupPreeclampsia diagnosisWeeks postpartumHistorical controlsFemale volunteersNon-pregnant female volunteersContinuous arterial blood pressureArterial blood pressureNon-pregnant volunteersDiagnosis of preeclampsiaHealthy non-pregnant female volunteersCerebrovascular complicationsBlood pressureTranscranial DopplerPostpartum participantsAutoregulatory responseFinger plethysmographyKruskal-Wallis testPreeclampsiaAutoregulation parametersPolygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors
Acosta J, Both C, Demarais Z, Conlon C, Leasure A, Torres-Lopez V, de Havenon A, Petersen N, Gill T, Sansing L, Sheth K, Falcone G. Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors. Neurology 2023, 100: e1587-e1597. PMID: 36690452, PMCID: PMC10103110, DOI: 10.1212/wnl.0000000000206763.Peer-Reviewed Original ResearchConceptsWorse BP controlUncontrolled blood pressureDiastolic blood pressureBlood pressureStroke survivorsPolygenic risk scoresBP controlPolygenic susceptibilityMean diastolic blood pressureMean systolic blood pressureStroke Prevention TrialBlood pressure controlSystolic blood pressureResistant hypertensionVascular eventsHemorrhagic strokePrevention trialsVitamin InterventionMultivariable modelRisk scoreGenetic predispositionPressure controlLogistic regressionSurvivorsHypertension
2020
Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke
Petersen NH, Silverman A, Strander SM, Kodali S, Wang A, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Jasne AS, Cord B, Hebert RM, Johnson M, Matouk CC, Sheth KN. Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke. Stroke 2020, 51: 914-921. PMID: 32078493, PMCID: PMC7050651, DOI: 10.1161/strokeaha.119.026596.Peer-Reviewed Original ResearchConceptsSystolic BP thresholdMean arterial pressureArterial pressureEndovascular thrombectomyIschemic strokeSystolic BPFunctional outcomePercent timeFurther brain injuryModified Rankin ScaleBlood pressure changesPoor functional outcomeBP thresholdAutoregulatory indexHemorrhagic transformationMechanical thrombectomyRankin ScaleBlood pressureBP targetsHemodynamic managementAcute phaseBP managementStroke patientsCerebral autoregulationWorse outcomes
2019
Changes on Dynamic Cerebral Autoregulation Are Associated with Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage
Ortega-Gutierrez S, Samaniego E, Reccius A, Huang A, Zheng-Lin B, Masukar A, Marshall R, Petersen N. Changes on Dynamic Cerebral Autoregulation Are Associated with Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement 2019, 127: 149-153. PMID: 31407076, DOI: 10.1007/978-3-030-04615-6_22.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationAneurysmal subarachnoid hemorrhageCerebral blood flow velocityBlood pressureSymptomatic vasospasmCerebral ischemiaSAH patientsCerebral autoregulationSubarachnoid hemorrhageCerebral blood flow regulationGlasgow Coma ScoreSystemic blood pressureDelayed Cerebral IschemiaLarge cohort studyBlood flow regulationBlood flow velocityRecording periodDCA assessmentCohort studyComa ScoreEntire recording periodSymptom onsetMedian timeDay 3Early identification
2018
105 Decreases in Blood Pressure During Endovascular Stroke Therapy Are Common and Associated With Poor Functional Outcome
Mampre D, Wang A, Sheth K, Tan C, Hebert R, Matouk C, Petersen N. 105 Decreases in Blood Pressure During Endovascular Stroke Therapy Are Common and Associated With Poor Functional Outcome. Neurosurgery 2018, 65: 82. DOI: 10.1093/neuros/nyy303.105.Peer-Reviewed Original ResearchDecreases in Blood Pressure During Endovascular Stroke Therapy are Common and Associated with Poor Functional Outcome (S21.004)
Wang A, Mampre D, Sheth K, Tan C, Hebert R, Matouk C, Petersen N. Decreases in Blood Pressure During Endovascular Stroke Therapy are Common and Associated with Poor Functional Outcome (S21.004). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.s21.004.Peer-Reviewed Original Research
2015
Dynamic Cerebral Autoregulation Is Transiently Impaired for One Week after Large-Vessel Acute Ischemic Stroke
Petersen NH, Ortega-Gutierrez S, Reccius A, Masurkar A, Huang A, Marshall RS. Dynamic Cerebral Autoregulation Is Transiently Impaired for One Week after Large-Vessel Acute Ischemic Stroke. Cerebrovascular Diseases 2015, 39: 144-150. PMID: 25661277, PMCID: PMC4754197, DOI: 10.1159/000368595.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationLarge-vessel ischemic strokeUnaffected hemisphereAffected hemisphereIschemic strokeCerebral autoregulationBlood pressureAcute large-vessel ischemic strokeLarge vessel acute ischemic strokeAcute blood pressure managementMiddle cerebral artery territoryAcute ischemic strokeBlood pressure managementCerebral blood flowBlood flow velocityDay strokePoor autoregulationAcute strokeArtery territoryArterial catheterTranscranial DopplerAffected sideUnaffected sideControl subjectsHealthy controls