Histone Deacetylase 3 Regulates Smooth Muscle Differentiation in Neural Crest Cells and Development of the Cardiac Outflow Tract
Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA. Histone Deacetylase 3 Regulates Smooth Muscle Differentiation in Neural Crest Cells and Development of the Cardiac Outflow Tract. Circulation Research 2011, 109: 1240-1249. PMID: 21959220, PMCID: PMC3225257, DOI: 10.1161/circresaha.111.255067.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal MedullaAnimalsAorta, ThoracicCell DifferentiationCell LineageCell MovementDouble Outlet Right VentricleFemaleFetal HeartGene Expression Regulation, DevelopmentalHeart Defects, CongenitalHeart Septal Defects, VentricularHeart VentriclesHistone DeacetylasesMaleMiceMice, TransgenicMuscle, SmoothNeural CrestPaired Box Transcription FactorsPAX3 Transcription FactorReceptors, NotchThymus GlandWnt1 ProteinConceptsNeural crest cellsCardiac outflow tractMuscle differentiationSmooth muscle differentiationCrest cellsCardiac neural crest developmentMultiple progenitor cell populationsFunctions of Hdac3Loss of Hdac3Neural crest cell migrationNeural crest developmentSmooth muscle lineageCrest cell migrationNumerous signaling pathwaysHistone deacetylase 3Role of epigeneticsProgenitor cell populationsSpecific regulatory roleNeural crest derivativesNotch ligand Jagged1OFT formationNeural crest resultsMammalian developmentMuscle lineageEpigenetic regulationDiet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle
Sun Z, Singh N, Mullican SE, Everett LJ, Li L, Yuan L, Liu X, Epstein JA, Lazar MA. Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle. Journal Of Biological Chemistry 2011, 286: 33301-33309. PMID: 21808063, PMCID: PMC3190900, DOI: 10.1074/jbc.m111.277707.Peer-Reviewed Original ResearchConceptsNutritional environmentProper mitochondrial functionHistone deacetylase 3Bioenergetic genesSkeletal muscleNucleosomal histonesHDAC3 geneGene expressionCovalent modificationHuman diseasesHDAC3Mitochondrial functionEmbryonic deletionCardiac mitochondriaGenesLipid metabolismDeletionMilder phenotypePhenotypeMajor cardiomyopathiesLethalityEpigenomeGenomeHistonesMouse model