2023
An expanded safety/feasibility study of the EMulate Therapeutics Voyager™ System in patients with recurrent glioblastoma
Barkhoudarian G, Badruddoja M, Blondin N, Chowdhary S, Cobbs C, Duic J, Flores J, Fonkem E, McClay E, Nabors L, Salacz M, Taylor L, Vaillant B, Gill J, Kesari S. An expanded safety/feasibility study of the EMulate Therapeutics Voyager™ System in patients with recurrent glioblastoma. CNS Oncology 2023, 12: cns102. PMID: 37462385, PMCID: PMC10410686, DOI: 10.2217/cns-2022-0016.Peer-Reviewed Original ResearchConceptsMedian overall survivalProgression-free survivalOverall survivalRecurrent glioblastomaAdverse eventsTherapy groupMedian progression-free survivalDevice-related adverse eventsSafety/feasibilitySerious adverse eventsFurther prospective studiesConcurrent therapyInvestigator's discretionStandard chemotherapyProspective studyTRIAL REGISTRATIONPatientsMonthsTreatmentHome-use deviceGlioblastomaWeeksSurvivalTotalGroup
2021
Surgical strategies for older patients with glioblastoma
Barak T, Vetsa S, Nadar A, Jin L, Gupte TP, Fomchenko EI, Miyagishima DF, Yalcin K, Vasandani S, Gorelick E, Zhao AY, Antonios J, Theriault BC, Lifton N, Marianayagam N, Omay B, Omay ZE, Huttner A, McGuone D, Blondin NA, Corbin Z, Fulbright RK, Moliterno J. Surgical strategies for older patients with glioblastoma. Journal Of Neuro-Oncology 2021, 155: 255-264. PMID: 34626296, PMCID: PMC8651607, DOI: 10.1007/s11060-021-03862-z.Peer-Reviewed Original ResearchConceptsKarnofsky performance scoreLength of surgeryOlder patientsOverall survivalPostoperative complicationsSurgical resectionSurgical strategyLow preoperative KPS scorePoor Karnofsky performance scoreLow Karnofsky performance scoreYale-New Haven HospitalPostoperative adjuvant treatmentPreoperative KPS scoreAdjuvant treatment regimensExtent of resectionNew Haven HospitalUse of ioMRIAdjuvant treatmentHospital stayKPS scoreMethodsClinical dataConsecutive patientsPrognostic factorsTreatment regimensExperienced handsType of bony involvement predicts genomic subgroup in sphenoid wing meningiomas
Jin L, Youngblood MW, Gupte TP, Vetsa S, Nadar A, Barak T, Yalcin K, Aguilera SM, Mishra-Gorur K, Blondin NA, Gorelick E, Omay SB, Pointdujour-Lim R, Judson BL, Alperovich M, Aboian MS, McGuone D, Gunel M, Erson-Omay Z, Fulbright RK, Moliterno J. Type of bony involvement predicts genomic subgroup in sphenoid wing meningiomas. Journal Of Neuro-Oncology 2021, 154: 237-246. PMID: 34350560, DOI: 10.1007/s11060-021-03819-2.Peer-Reviewed Original ResearchConceptsSpheno-orbital meningiomasSphenoid wing meningiomaBony involvementTRAF7 mutationsGenomic subgroupsPre-operative clinical featuresTumor invasionYale-New Haven HospitalAdditional clinical variablesSubset of tumorsPre-operative predictionWhole-exome sequencingBone involvementBone invasionClinical featuresClinical variablesGrade IIMolecular subtypesRecurrence patternsClinical implicationsHyperostosisExome sequencingMeningiomasTumorsGenomic drivers
2016
Planning TTFields treatment using the NovoTAL system-clinical case series beyond the use of MRI contrast enhancement
Connelly J, Hormigo A, Mohilie N, Hu J, Chaudhry A, Blondin N. Planning TTFields treatment using the NovoTAL system-clinical case series beyond the use of MRI contrast enhancement. BMC Cancer 2016, 16: 842. PMID: 27809808, PMCID: PMC5096303, DOI: 10.1186/s12885-016-2890-0.Peer-Reviewed Original ResearchConceptsCase seriesAdvanced imagingTreatment planningCommon primary brain tumorNon-contrast enhancementPostcontrast MRI scansStandard care pathwayRecent clinical studiesPrimary brain tumorsContrast enhancementMagnetic resonance imaging (MRI) measurementsTumor Treating FieldsStandard treatment planningPrior therapyDisease activityNonmeasurable diseaseStandard therapySurvival benefitTumor burdenPoor prognosisTumor locationCare pathwayClinical evaluationClinical trialsPatient outcomes
2012
Anaplastic Gliomas Radiation, Chemotherapy, or Both?
Blondin NA, Becker KP. Anaplastic Gliomas Radiation, Chemotherapy, or Both? Hematology/Oncology Clinics Of North America 2012, 26: 811-823. PMID: 22794285, DOI: 10.1016/j.hoc.2012.04.003.Peer-Reviewed Original ResearchPlantar Flexion with Noxious Dorsal Foot Stimulation in Brain Death
Hernandez AL, Blondin NA, Curiale G, Greer DM. Plantar Flexion with Noxious Dorsal Foot Stimulation in Brain Death. Neurocritical Care 2012, 17: 268-270. PMID: 22528275, DOI: 10.1007/s12028-012-9697-x.Peer-Reviewed Original ResearchConceptsBrain deathPlantar flexionSevere anoxic brain injuryAnoxic brain injuryArthroscopic knee surgeryBrain-dead patientsDorsal surfaceMethodsCase reportFoot stimulationCerebral perfusionNeurologic examinationNuclear scanDead patientsKnee surgeryBrain injuryNoxious stimulationPlantar stimulationAncillary testingGreat toeBrain scansTechnetium-99FlexionDeathStimulationPatients
2011
Paraneoplastic Syndrome of Inappropriate Antidiuretic Hormone Mimicking Limbic Encephalitis
Blondin NA, Vortmeyer AO, Harel NY. Paraneoplastic Syndrome of Inappropriate Antidiuretic Hormone Mimicking Limbic Encephalitis. JAMA Neurology 2011, 68: 1591-1594. PMID: 22159058, DOI: 10.1001/archneurol.2011.876.Peer-Reviewed Original ResearchConceptsLimbic encephalitisAntidiuretic hormoneParaneoplastic syndromeEctopic secretionMemory impairmentCerebrospinal fluid analysis findingsClassic limbic encephalitisParaneoplastic limbic encephalitisInappropriate antidiuretic hormoneProgressive memory impairmentAcademic medical centerMagnetic resonance imagingPositron emission tomographyOccult malignancyChronic hyponatremiaThorough workupClinical featuresNeuroendocrine tumorsDifferential diagnosisMedical CenterImmunohistochemical analysisEncephalitisResonance imagingEmission tomographyHyponatremiaUnilateral Tongue Atrophy and Fasciculation
Blondin NA, Huttner A, Baehring JM. Unilateral Tongue Atrophy and Fasciculation. JAMA Neurology 2011, 68: 1478-1478. PMID: 22084136, DOI: 10.1001/archneurol.2011.652.Peer-Reviewed Original ResearchFirst-order Horner syndrome due to ipsilateral thalamic hemorrhage
Sawires M, Berek K, Blondin N, Schindler J. First-order Horner syndrome due to ipsilateral thalamic hemorrhage. Neurology 2011, 77: 1019. PMID: 21893675, DOI: 10.1212/wnl.0b013e31822470d4.Peer-Reviewed Original ResearchNeurologic Prognosis in Cardiac Arrest Patients Treated With Therapeutic Hypothermia
Blondin NA, Greer DM. Neurologic Prognosis in Cardiac Arrest Patients Treated With Therapeutic Hypothermia. The Neurologist 2011, 17: 241-248. PMID: 21881465, DOI: 10.1097/nrl.0b013e318224ee0e.Peer-Reviewed Original ResearchConceptsTherapeutic hypothermiaCardiac arrestNeurologic prognosisNeurologic outcomeGood neurologic outcomeCardiac arrest patientsNeurology practice parameterNeuromuscular blocking agentsCerebrospinal fluid biomarkersEligible patientsNeurologic prognosticationNeurophysiologic testingArrest patientsNeurophysiologic findingsPoor prognosisClinical examinationFluid biomarkersPharmacologic effectsBlocking agentPhysiologic effectsPractice parametersClinical examBetter outcomesPatientsPrognosisTeaching NeuroImages: First-order Horner syndrome due to ipsilateral thalamic hemorrhage
Blondin NA, Schindler JL. Teaching NeuroImages: First-order Horner syndrome due to ipsilateral thalamic hemorrhage. Neurology 2011, 76: e14. PMID: 21263131, DOI: 10.1212/wnl.0b013e31820882db.Peer-Reviewed Original Research
2010
Thrombolysis in Right versus Left Hemispheric Stroke
Blondin NA, Staff I, Lee N, McCullough LD. Thrombolysis in Right versus Left Hemispheric Stroke. Journal Of Stroke And Cerebrovascular Diseases 2010, 19: 269-272. PMID: 20471856, DOI: 10.1016/j.jstrokecerebrovasdis.2009.04.012.Peer-Reviewed Original ResearchConceptsLeft hemispheric strokeRight hemispheric strokeT-PA administrationHemispheric strokeAcute strokeStroke centersEmergency departmentT-PAIntravenous recombinant tissue plasminogen activatorRecombinant tissue plasminogen activatorLarge community populationLarge prospective cohortPoor clinical outcomeT-PA useRight hemispheric syndromeTissue plasminogen activatorAffected hemisphereIschemic strokeProspective cohortClinical outcomesHemispheric syndromeStudy inclusionStudy populationPatientsStroke