2021
Hypermutated phenotype in gliosarcoma of the spinal cord
Hong CS, Kuzmik GA, Kundishora AJ, Elsamadicy AA, Koo AB, McGuone D, Blondin NA, DiLuna ML, Erson-Omay EZ. Hypermutated phenotype in gliosarcoma of the spinal cord. Npj Precision Oncology 2021, 5: 8. PMID: 33580181, PMCID: PMC7881101, DOI: 10.1038/s41698-021-00143-w.Peer-Reviewed Original ResearchSpinal cordWhole-exome sequencingLow-grade brain gliomasVariant of glioblastomaLow-grade gliomasTumor anteriorAdjuvant radiationNeurological deficitsSomatic single nucleotide variationsPoor prognosisGrade gliomasTemozolomide treatmentBrain gliomasGliosarcomaMicrosatellite stabilityCordSomatic mutationsHypermutator phenotypeGliomasComprehensive genetic characterizationGenomic mechanismsSingle nucleotide variationsPhenotypeFirst reportPathway genes
2016
Planning TTFields treatment using the NovoTAL system-clinical case series beyond the use of MRI contrast enhancement
Connelly J, Hormigo A, Mohilie N, Hu J, Chaudhry A, Blondin N. Planning TTFields treatment using the NovoTAL system-clinical case series beyond the use of MRI contrast enhancement. BMC Cancer 2016, 16: 842. PMID: 27809808, PMCID: PMC5096303, DOI: 10.1186/s12885-016-2890-0.Peer-Reviewed Original ResearchConceptsCase seriesAdvanced imagingTreatment planningCommon primary brain tumorNon-contrast enhancementPostcontrast MRI scansStandard care pathwayRecent clinical studiesPrimary brain tumorsContrast enhancementMagnetic resonance imaging (MRI) measurementsTumor Treating FieldsStandard treatment planningPrior therapyDisease activityNonmeasurable diseaseStandard therapySurvival benefitTumor burdenPoor prognosisTumor locationCare pathwayClinical evaluationClinical trialsPatient outcomesACTR-08. BENEFICIAL EFFECT OF TUMOR TREATING FIELD THERAPY IN DIFFUSE ASTROCYTOMA WITH GLIOMATOSIS CEREBRI
Blondin N. ACTR-08. BENEFICIAL EFFECT OF TUMOR TREATING FIELD THERAPY IN DIFFUSE ASTROCYTOMA WITH GLIOMATOSIS CEREBRI. Neuro-Oncology 2016, 18: vi3-vi3. DOI: 10.1093/neuonc/now212.007.Peer-Reviewed Original ResearchSignificant radiographic improvementGliomatosis cerebriRadiographic improvementDiagnostic biopsyCerebral lobesRadiation therapyDiffuse astrocytomasTTFields therapyCombination of TTFieldsCycles of TMZYear old manYear old womanEffective treatment strategiesTumor treating fields therapyTumor Treating FieldsActive diseasePerformance statusRadiographic progressionSurvival benefitAdult astrocytomasNeurological toxicityPatient 1Patient 2Poor prognosisMalignant disease
2011
Neurologic Prognosis in Cardiac Arrest Patients Treated With Therapeutic Hypothermia
Blondin NA, Greer DM. Neurologic Prognosis in Cardiac Arrest Patients Treated With Therapeutic Hypothermia. The Neurologist 2011, 17: 241-248. PMID: 21881465, DOI: 10.1097/nrl.0b013e318224ee0e.Peer-Reviewed Original ResearchConceptsTherapeutic hypothermiaCardiac arrestNeurologic prognosisNeurologic outcomeGood neurologic outcomeCardiac arrest patientsNeurology practice parameterNeuromuscular blocking agentsCerebrospinal fluid biomarkersEligible patientsNeurologic prognosticationNeurophysiologic testingArrest patientsNeurophysiologic findingsPoor prognosisClinical examinationFluid biomarkersPharmacologic effectsBlocking agentPhysiologic effectsPractice parametersClinical examBetter outcomesPatientsPrognosis