Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic
Diehl WE, Lin AE, Grubaugh ND, Carvalho LM, Kim K, Kyawe PP, McCauley SM, Donnard E, Kucukural A, McDonel P, Schaffner SF, Garber M, Rambaut A, Andersen KG, Sabeti PC, Luban J. Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic. Cell 2016, 167: 1088-1098.e6. PMID: 27814506, PMCID: PMC5115602, DOI: 10.1016/j.cell.2016.10.014.Peer-Reviewed Original ResearchMeSH KeywordsAfrica, WesternAmino Acid SubstitutionAnimalsCallithrixCarrier ProteinsCheirogaleidaeCytoplasmEbolavirusHemorrhagic Fever, EbolaHumansIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsNiemann-Pick C1 ProteinProtein Conformation, alpha-HelicalViral Envelope ProteinsVirionVirulenceConceptsHuman dendritic cellsIncreased infectivityEbola virus disease epidemicHuman hostEbola virus glycoproteinDendritic cellsHuman transmission eventsEVD epidemicEBOV-GPDisease severityViral mutationsViral infectivityPrimate cellsIntrinsic infectivityTransmission eventsInfectivityEpidemicVirus glycoproteinDisease epidemicsCellsNonsynonymous mutationsMutationsOutbreakHigh frequencyMortality