2024
Diandric triploid partial mole versus digynic nonmolar triploidy: is morphological assessment sufficient for the diagnostic distinction?
Nagy A, Niu N, Sun T, Buza N, Hui P. Diandric triploid partial mole versus digynic nonmolar triploidy: is morphological assessment sufficient for the diagnostic distinction? Histopathology 2024, 85: 879-888. PMID: 39031756, DOI: 10.1111/his.15247.Peer-Reviewed Original ResearchPositive predictive valueTriploid gestationsPartial moleTrophoblastic hyperplasiaVillous sizeCistern formationHistological parametersPostmolar gestational trophoblastic neoplasiaTriploid partial molesGenotype-phenotype correlation studiesGestational trophoblastic neoplasiaPartial hydatidiform moleModerate interobserver agreementVillous populationsTrophoblastic neoplasiaGestational weeksHydatidiform moleClinical presentationPatient ageDigynic triploidyAbnormal histologyInterobserver agreementGestationSyncytiotrophoblastHistological assessment
2022
Dataset for the Reporting of Gestational Trophoblastic Neoplasia: Recommendations From the International Collaboration on Cancer Reporting (ICCR)
Hui P, Webster F, Baergen RN, Buza N, Cheung ANY, Kaur B, Ronnett BM, Shih IM, Seckl MJ, Lax SF, McCluggage WG. Dataset for the Reporting of Gestational Trophoblastic Neoplasia: Recommendations From the International Collaboration on Cancer Reporting (ICCR). International Journal Of Gynecological Pathology 2022, 41: s34-s43. PMID: 36305533, DOI: 10.1097/pgp.0000000000000876.Peer-Reviewed Original ResearchConceptsGestational trophoblastic neoplasiaTrophoblastic neoplasiaCancer reportingPathologic parametersTumor stagingCancer sitesPathology reportsPatient managementPatient careNeoplasiaNoncore elementsStagingTumor classificationPathologyInternational expertsDifferent populationsReportingCancer datasetsInternational collaboration
2021
Genotyping diagnosis of gestational trophoblastic disease: frontiers in precision medicine
Buza N, Hui P. Genotyping diagnosis of gestational trophoblastic disease: frontiers in precision medicine. Modern Pathology 2021, 34: 1658-1672. PMID: 34088998, DOI: 10.1038/s41379-021-00831-9.Peer-Reviewed Original ResearchConceptsGestational trophoblastic diseaseTrophoblastic diseaseGestational trophoblastic tumorsGestational trophoblastic neoplasiaRoutine diagnostic workupDNA genotypingSignificant clinical relevancePowerful ancillary toolFIGO/Genetic zygosityGestational eventIndex gestationTrophoblastic tumorTrophoblastic neoplasiaGestational choriocarcinomaPrognostic stratificationDiagnostic workupPrognostic assessmentClinical relevanceClinical practiceGestational originMolecular diagnostic capabilitiesPatient careSporadic hydatidiformCopy number alterations
2016
Putative Precursor Lesions of Gestational Trophoblastic Neoplasia
Buza N, Hui P. Putative Precursor Lesions of Gestational Trophoblastic Neoplasia. 2016, 85-102. DOI: 10.1007/978-3-319-22509-8_5.Peer-Reviewed Original ResearchPlacental site trophoblastic tumorEpithelioid trophoblastic tumorPlacental site nodulePrecursor lesionsTrophoblastic tumorRare caseAtypical placental site noduleRisk of progressionExaggerated placental siteGestational trophoblastic neoplasiaGestational trophoblastic neoplasmsSignificant cytological atypiaHistological diagnostic criteriaMajority of tumorsPossible precursor lesionsPutative precursor lesionsIntraplacental choriocarcinomaEctopic pregnancyTerm pregnancyTrophoblastic neoplasiaGestational choriocarcinomaNon-molar abortionsPlacental siteTrophoblastic neoplasmsCytological atypia
2011
Partial Hydatidiform Mole
Buza N. Partial Hydatidiform Mole. Current Clinical Pathology 2011, 77-90. DOI: 10.1007/978-1-61779-394-3_5.Peer-Reviewed Original ResearchGestational trophoblastic neoplasiaGestational trophoblastic diseasePersistent gestational trophoblastic diseasePartial Hydatidiform MoleClinical presentationTrophoblastic neoplasiaSubsequent riskTrophoblastic diseaseNonneoplastic proliferationTriploid gestationsVillous trophoblastDistinct subtypesTrophoblastic hyperplasiaHydatidiform MolePartial hydatidiformChorionic villiSignificant differencesHydatidiformGestationHyperplasiaNeoplasiaSubtypesDiseaseTrophoblastHistomorphology