2023
430. Calibrated fMRI Sensitive to Ketamine-Related Increases Throughout the Cortex
Driesen N, Herman P, Rowland M, Thompson G, Qiu M, He G, Criscuolo E, Fineberg S, Barron D, Helgeson L, Lacadie C, Chow R, Gueorguieva R, Straun T, Krystal J, Hyder F. 430. Calibrated fMRI Sensitive to Ketamine-Related Increases Throughout the Cortex. Biological Psychiatry 2023, 93: s268-s269. DOI: 10.1016/j.biopsych.2023.02.670.Peer-Reviewed Original Research
2021
The effect of ketamine on psychopathology and implications for understanding schizophrenia and its therapeutic use: a meta-analysis
Beck K, Hindley G, Borgan F, Ginestet C, McCutcheon R, Brugger S, Driesen N, Ranganathan M, D'Souza D, Taylor M, Krystal J, Howes O. The effect of ketamine on psychopathology and implications for understanding schizophrenia and its therapeutic use: a meta-analysis. BJPsych Open 2021, 7: s237-s237. PMCID: PMC8771247, DOI: 10.1192/bjo.2021.634.Peer-Reviewed Original ResearchBrief Psychiatric Rating ScaleEffects of ketaminePlacebo conditionPositive symptomsKetamine administrationKetamine effectsHealthy participantsHealthy volunteersNegative symptomsTherapeutic useAcute ketamine administrationAcute ketamine challengeMagnitude of symptomsStudy-level dataSub-group analysisPsychiatric Rating ScaleSchizophrenia-like symptomatologySchizophrenia-like symptomsMean change scoresNegative Syndrome ScalePositive psychotic symptomsSignificant increaseEffect sizeBolus dosesKetamine challenge
2016
Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses: Insights from Neuroimaging and Computational Neuroscience
Krystal J, Anticevic A, Murray J, Glahn D, Driesen N, Yang G, Wang X. Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses: Insights from Neuroimaging and Computational Neuroscience. 2016, 293-316. DOI: 10.7551/mitpress/10936.003.0023.Peer-Reviewed Original ResearchPsychiatric disordersMechanisms of psychiatric disordersModel psychiatric disordersPsychiatric nosologyPsychological assessmentPsychiatric diagnosingModern psychiatryPsychiatric issuesNeurobiologyPsychiatristsNeurological analysisPsychiatryDisordersComputational neuroscienceClinical heterogeneityNeuroimagingNosologyNeuroscienceNeuroscientistsComputational neuroscientistsCategorization
2013
Differentiating Patterns of Amygdala-Frontal Functional Connectivity in Schizophrenia and Bipolar Disorder
Liu H, Tang Y, Womer F, Fan G, Lu T, Driesen N, Ren L, Wang Y, He Y, Blumberg HP, Xu K, Wang F. Differentiating Patterns of Amygdala-Frontal Functional Connectivity in Schizophrenia and Bipolar Disorder. Schizophrenia Bulletin 2013, 40: 469-477. PMID: 23599250, PMCID: PMC3932086, DOI: 10.1093/schbul/sbt044.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityBipolar disorderBD groupPrefrontal cortexHealthy controlsFunctional connectivityResting-state functional magnetic resonance imagingNeural system abnormalitiesDorsal lateral prefrontal cortexFunctional magnetic resonance imagingMagnetic resonance imagingVentral prefrontal cortexClinical characteristicsSystem abnormalitiesSuperficial amygdalaAnatomic mapAmygdala subregionsHC groupResonance imagingLateral prefrontal cortexAmygdalaSZ groupSchizophreniaDisordersSignificant differences
2009
Behavioral and neural correlates of memory selection and interference resolution during a digit working memory task
Yi Y, Driesen N, Leung HC. Behavioral and neural correlates of memory selection and interference resolution during a digit working memory task. Cognitive, Affective, & Behavioral Neuroscience 2009, 9: 249-259. PMID: 19679761, PMCID: PMC2741611, DOI: 10.3758/cabn.9.3.249.Peer-Reviewed Original ResearchConceptsProactive interferenceMemory selectionNeural correlatesEffects of PILeft inferior parietal lobePrefrontal-parietal networkStrong proactive interferenceTask-relevant informationInferior parietal lobeResponse time differencesMiddle frontal gyrusPosterior parietal cortexInterference resolutionMemory taskFrontal gyrusRecognition taskRelevant digitsSelection cuesDelay intervalPrecue intervalsParietal cortexInformation processingParietal lobeTaskCorrelatesNMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans
Driesen N, McCarthy G, Bhagwagar Z, Calhoun V, D'Souza D, Holub J, Morgan P, Krystal J. NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans. NeuroImage 2009, 47: s145. DOI: 10.1016/s1053-8119(09)71458-2.Peer-Reviewed Original Research
2008
Impairment of Working Memory Maintenance and Response in Schizophrenia: Functional Magnetic Resonance Imaging Evidence
Driesen NR, Leung HC, Calhoun VD, Constable RT, Gueorguieva R, Hoffman R, Skudlarski P, Goldman-Rakic PS, Krystal JH. Impairment of Working Memory Maintenance and Response in Schizophrenia: Functional Magnetic Resonance Imaging Evidence. Biological Psychiatry 2008, 64: 1026-1034. PMID: 18823880, PMCID: PMC2650279, DOI: 10.1016/j.biopsych.2008.07.029.Peer-Reviewed Original ResearchConceptsMemory taskPrefrontal activityMemory maintenanceBrain activationFunctional Magnetic Resonance Imaging EvidenceWorking Memory MaintenanceCognitive impairmentHealthy comparison participantsPrefrontal cortical activityFunctional magnetic resonanceMemory loadComparison participantsTask accuracyDistinct neurobiologyCortical activityHealthy participantsBasic research insightsImaging EvidenceMemoryCortical deficitsCortical functionPoor performanceTaskSchizophreniaResponse phase
2006
Brain Connectivity Related to Working Memory Performance
Hampson M, Driesen NR, Skudlarski P, Gore JC, Constable RT. Brain Connectivity Related to Working Memory Performance. Journal Of Neuroscience 2006, 26: 13338-13343. PMID: 17182784, PMCID: PMC2677699, DOI: 10.1523/jneurosci.3408-06.2006.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMemory taskCognitive tasksCingulate cortexVentral anterior cingulate cortexDifferent cognitive tasksMedial frontal regionsMedial frontal gyrusDefault mode networkAnterior cingulate cortexFunctional imaging studiesCognitive abilitiesIndividual differencesMemory performanceCognitive performanceFrontal gyrusMode networkFrontal regionsFunctional connectivityBrain connectivityBrain areasTaskFunctional connectionsImaging studiesCortexHypoglycemia reduces the blood‐oxygenation level dependent signal in primary auditory and visual cortex: A functional magnetic resonance imaging study
Driesen NR, Goldberg PA, Anderson AW, Tang L, Flanagan DE, Sherwin RS, Gore JC. Hypoglycemia reduces the blood‐oxygenation level dependent signal in primary auditory and visual cortex: A functional magnetic resonance imaging study. Journal Of Neuroscience Research 2006, 85: 575-582. PMID: 17154420, DOI: 10.1002/jnr.21146.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingFunctional magnetic resonance imagingModerate hypoglycemiaVisual cortexResonance imagingCentral nervous system effectsMagnetic resonance imaging studyNon-diabetic controlsNon-diabetic participantsNervous system effectsBlood oxygenation level-dependent (BOLD) signalFrequent hypoglycemic episodesBlood oxygenation level-dependent (BOLD) responseEffects of hypoglycemiaResonance imaging studyFunctional magnetic resonance imaging studyLevel-dependent signalLevel-dependent responsesVisual stimuliHypoglycemic episodesT1DM patientsPrimary auditoryEuglycemic periodHypoglycemic responseNeurophysiologic changes
1999
Symptom Assessment in Schizophrenic Prodromal States
Miller T, McGlashan T, Woods S, Stein K, Driesen N, Corcoran C, Hoffman R, Davidson L. Symptom Assessment in Schizophrenic Prodromal States. Psychiatric Quarterly 1999, 70: 273-287. PMID: 10587984, DOI: 10.1023/a:1022034115078.Peer-Reviewed Original ResearchConceptsProdromal symptomsEarly interventionLife-long illnessLong-term courseOnset of schizophreniaPublic health implicationsBetter prognosisSymptom assessmentAvailable treatmentsProdromal patientsPsychotic illnessProdromal stateProdromal stageSymptom severityNeurobiological deficitsIllnessHealth implicationsPatientsLong illnessSymptomsStructured interviewsSchizophreniaClinical workInterventionAssessment instruments
1995
The influence of sex, age, and handedness on corpus callosum morphology: A meta-analysis
Driesen N, Raz N. The influence of sex, age, and handedness on corpus callosum morphology: A meta-analysis. Cognitive, Affective, & Behavioral Neuroscience 1995, 23: 240-247. DOI: 10.3758/bf03332028.Peer-Reviewed Original ResearchReaction Time Impairment in Insulin-Dependent Diabetes: Task Complexity, Blood Glucose Levels, and Individual Differences
Driesen N, Cox D, Gonder-Frederick L, William C. Reaction Time Impairment in Insulin-Dependent Diabetes: Task Complexity, Blood Glucose Levels, and Individual Differences. Neuropsychology 1995, 9: 246-254. DOI: 10.1037/0894-4105.9.2.246.Peer-Reviewed Original ResearchIndividual differencesRT taskReaction timeComplex RT tasksCognitive processing speedIndividual difference variablesMeasures cross-over designReaction time impairmentsSimple RT taskTest 4 timesCognitive slowingDifference variablesTask complexityProcessing speedHypoglycemia sensitivityParticipantsCross-over designTaskEffects of hypoglycemiaModerate hypoglycemiaImpairmentExperimental daysAdultsIndividualsDay protocolIndividual Differences in Neurobehavioral Disruption During Mild and Moderate Hypoglycemia in Adults with IDDM
A G, Cox D, Driesen N, Ryan C, Clarke W. Individual Differences in Neurobehavioral Disruption During Mild and Moderate Hypoglycemia in Adults with IDDM. The Endocrinologist 1995, 5: 162. DOI: 10.1097/00019616-199503000-00027.Peer-Reviewed Original ResearchSelective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry.
Raz N, Torres I, Briggs S, Spencer W, Thornton A, Loken W, Gunning F, McQuain J, Driesen N, Acker J. Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry. Neurology 1995, 45: 356-66. PMID: 7854539, DOI: 10.1212/wnl.45.2.356.Peer-Reviewed Original ResearchConceptsDS subjectsDown syndromeNeuroanatomic abnormalitiesParahippocampal gyrusWhite matterBrain regionsSex-matched healthy volunteersDisease hypothesisAnterior cingulate gyrusParietal white matterPrefrontal white matterPremature agingDorsolateral prefrontal cortexCerebral damageThyroid dysfunctionAge-related declineSeizure disorderSignificant group differencesBasal gangliaBrain abnormalitiesCardiovascular diseaseMammillary bodiesCerebellar hemispherePostcentral gyrusCingulate gyrus- Driesen, N.R., Cox, D.J., Gonder-Frederick, L., Clarke, W. (1995). Reaction time impairment in insulin dependent diabetes: task complexity, blood glucose levels and individual differences. Neuropsychology, 9, 246-254.Peer-Reviewed Original Research
- Driesen, N.R. & Raz, N. (1995). The influence of sex, age and handedness on corpus callosum morphology: a meta-analysis. Psychobiology, 23, 240-247.Peer-Reviewed Original Research
1994
Individual Differences in Neurobehavioral Disruption During Mild and Moderate Hypoglycemia in Adults With IDDM
Gonder-Frederick L, Cox D, Driesen N, Ryan C, Clarke W. Individual Differences in Neurobehavioral Disruption During Mild and Moderate Hypoglycemia in Adults With IDDM. Diabetes 1994, 43: 1407-1412. PMID: 7958491, DOI: 10.2337/diab.43.12.1407.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetes mellitusModerate hypoglycemiaDegree of impairmentHistory of unconsciousnessNeurobehavioral deteriorationDiabetes mellitusGlycemic thresholdsTest four timesMild hypoglycemiaDay protocolNeurobehavioral disruptionNeurobehavioral effectsGlycemic recoveryHypoglycemiaMore deteriorationRepeat testingCrossover designControl dayDeterioration scoresConsecutive daysExperimental daysImpairmentIndividual differences in neurobehavioral disruption during mild and moderate hypoglycemia in adults with IDDM
Gonder-Frederick L, Cox D, Driesen N, Ryan C, Clarke W. Individual differences in neurobehavioral disruption during mild and moderate hypoglycemia in adults with IDDM. Diabetes 1994, 43: 1407-1412. DOI: 10.2337/diabetes.43.12.1407.Peer-Reviewed Original ResearchReliability of Driving Performance During Moderate Hypoglycemia in Adults With IDDM
Quillian W, Cox D, Gonder-Frederick L, Driesen N, Clarke W. Reliability of Driving Performance During Moderate Hypoglycemia in Adults With IDDM. Diabetes Care 1994, 17: 1367-1368. PMID: 7821187, DOI: 10.2337/diacare.17.11.1367.Peer-Reviewed Original Research
1993
Malignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases
Wanebo J, Malik J, Vandenberg S, Wanebo H, Driesen N, Persing J. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases. Cancer 1993, 71: 1247-1253. PMID: 8435801, DOI: 10.1002/1097-0142(19930215)71:4<1247::aid-cncr2820710413>3.0.co;2-s.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorDisease-free survivalSurgical marginsTumor sizeTumor locationSurvival timeMedian disease-free survival timeBetter disease-free survivalMedian overall survival timePeripheral nerve sheath tumorsDisease-free survival timeVirginia Health Sciences CenterAdjuvant radiation therapyExtent of surgeryWide surgical marginsNerve sheath tumorsOverall survival timeQuality of marginsNeurofibromatosis type 1Type of treatmentHealth Sciences CenterAggressive surgeryClinicopathologic studyOverall survivalPatient age