The Contribution of Insulitis to Diabetes Development in Tumor Necrosis Factor Transgenic Mice
Flavell RA, Kratz A, Ruddle NH. The Contribution of Insulitis to Diabetes Development in Tumor Necrosis Factor Transgenic Mice. Current Topics In Microbiology And Immunology 1996, 206: 33-50. PMID: 8608724, DOI: 10.1007/978-3-642-85208-4_3.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetes mellitusTumor necrosis factor-transgenic (TNF-Tg) miceDevelopment of diabetesHLA susceptibility allelesIslets of LangerhansHLA-DQβDiabetes mellitusFrank diabetesTransgenic miceStrong associationSusceptibility allelesDiabetesIdentical twinsDiseaseInsulinIsletsInsulitisSite of synthesisMellitusNumber of yearsPatientsMiceEnvironmental factors