2024
Tertiary Lymphoid Structures and Immunotherapy: Challenges and Opportunities
Ruddle N. Tertiary Lymphoid Structures and Immunotherapy: Challenges and Opportunities. Methods In Molecular Biology 2024, 2864: 299-312. PMID: 39527229, DOI: 10.1007/978-1-0716-4184-2_16.Peer-Reviewed Original ResearchConceptsImmune-related adverse eventsImmune checkpoint inhibitorsTertiary lymphoid structuresSecondary lymphoid organsTA-TLSSusceptibility to immune-related adverse eventsAssociated with favorable clinical outcomesPositive response to immunotherapyResponse to immunotherapyFavorable clinical outcomesCellular compositionVascular growth factorsAccumulation of lymphoid cellsCheckpoint inhibitorsLymphoid neogenesisLymphoid structuresProcess of lymphoid neogenesisClinical outcomesAdenovirus vectorLymphoid cellsTumor-associatedAdverse eventsTumor environmentOrgan rejectionChronic inflammation
2023
Regulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer
Ruddle N. Regulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer. Current Opinion In Physiology 2023, 36: 100705. PMID: 38523879, PMCID: PMC10956444, DOI: 10.1016/j.cophys.2023.100705.Peer-Reviewed Original ResearchHigh endothelial venulesTertiary lymphoid structuresLymphoid organsEndothelial venulesImmune checkpoint blockadeFavorable clinical outcomeAdhesion molecule-1Peripheral node addressinAutoimmune lesionsCheckpoint blockadeClinical outcomesEffector cellsChronic inflammationLymphoid structuresAcute inflammationLymphoid cellsMolecule-1InflammationCentral memoryAdhesion moleculesBlood vesselsPrecursor cellsImmunotherapyVenulesOrgans